{"id":"W4415215835","doi":"10.1016/s1474-4422(25)00308-4","title":"Intravenous alteplase versus oral aspirin for acute central retinal artery occlusion within 4·5 h of severe vision loss (THEIA): a multicentre, double-dummy, patient-blinded and assessor-blinded, randomised, controlled, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Retinal and Optic Conditions","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Direction de l’hospitalisation et de l’offre de Soins; Ministère des Solidarités et de la Santé; Boehringer Ingelheim France; Boehringer Ingelheim","keywords":"Central retinal artery occlusion; Aspirin; Occlusion; Central retinal artery; Vision disorder; Retinal; Eye disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005019968,0.001936653,0.004984483,0.0005054956,0.0005916796,0.001620781,0.001135028,0.002364986,0.004657037],"category_scores_gemma":[0.005349613,0.0007337903,0.005037306,0.0005579995,0.001015029,0.001073365,0.0005907352,0.002801937,0.0007236997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013575,"about_ca_system_score_gemma":0.00130872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009421092,"about_ca_topic_score_gemma":0.001728331,"domain_scores_codex":[0.9974057,0.001619141,0.0002453085,0.0003518354,0.0001375883,0.0002403902],"domain_scores_gemma":[0.9971794,0.0009452644,0.0009981254,0.0002382028,0.0002353184,0.0004036273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9895739,0.001479123,0.0003707882,0.001280373,0.001878922,0.00001880583,0.0000436691,0.0001369144,0.0008484003,0.00005955984,0.0002558932,0.004053487],"study_design_scores_gemma":[0.9633103,0.03335161,0.001030175,0.00007938586,0.001534011,0.00001495297,0.00001362258,0.0001470095,0.0001234287,0.00008154809,0.0003038525,0.00001023433],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611159,0.01724564,0.001602274,0.001231523,0.001294803,0.01301105,0.001873753,0.0001730752,0.002451994],"genre_scores_gemma":[0.9766839,0.004144893,0.00229642,0.00134088,0.00073964,0.01248597,0.0009063472,0.00002816427,0.001373768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005019968,"threshold_uncertainty_score":0.02654845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0375417818587189,"score_gpt":0.3607177842767156,"score_spread":0.3231760024179967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}