{"id":"W4415219034","doi":"10.1016/j.xcrm.2025.102414","title":"Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Research Council; Horizon 2020 Framework Programme; China Scholarship Council; European Commission; University of Calgary; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Toegepaste en Technische Wetenschappen, NWO; Universiteit Utrecht; H2020 European Research Council; Canada Research Chairs","keywords":"Isotype; Antibody; Escherichia coli; Streptococcus pyogenes; Antigen; Streptococcus; Immunoglobulin G; Neisseria gonorrhoeae; Effector","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009888842,0.0002730081,0.0006758012,0.000329308,0.000143876,0.00001366489,0.0001839873,0.0001756075,0.001457633],"category_scores_gemma":[0.0005714634,0.0001753021,0.000166027,0.0008836242,0.0003756428,0.00003521197,0.0001874066,0.0004289846,0.00004106752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094111,"about_ca_system_score_gemma":0.0003889392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006600255,"about_ca_topic_score_gemma":0.00002362224,"domain_scores_codex":[0.9973053,0.0001062993,0.0007967307,0.0005891314,0.0007790498,0.0004234386],"domain_scores_gemma":[0.9974853,0.0002897916,0.0002504665,0.00126656,0.0004227971,0.0002851045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008461171,0.0002892084,0.003932228,0.000292484,0.00006117966,0.0003765854,0.000726699,0.000002155655,0.9336004,0.00002590346,0.05406503,0.00578206],"study_design_scores_gemma":[0.00106723,0.0005224734,0.005973433,0.0003175172,0.0001210448,0.00005565946,0.000726143,0.00001245051,0.5841337,0.00003188392,0.4069202,0.0001182465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665535,0.001270528,0.0002119885,0.006582785,0.001140923,0.001080166,0.000009621368,0.00005121873,0.02309928],"genre_scores_gemma":[0.9926209,0.0003906784,0.00007978245,0.0005476869,0.0006474108,0.00002807555,0.00004281137,0.00003446788,0.005608183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3528551,"threshold_uncertainty_score":0.9994552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843874188284737,"score_gpt":0.2916163009729533,"score_spread":0.2731775590901059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}