{"id":"W4415219034","doi":"10.1016/j.xcrm.2025.102414","title":"Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Research Council; Horizon 2020 Framework Programme; China Scholarship Council; European Commission; University of Calgary; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Toegepaste en Technische Wetenschappen, NWO; Universiteit Utrecht; H2020 European Research Council; Canada Research Chairs","keywords":"Isotype; Antibody; Escherichia coli; Streptococcus pyogenes; Antigen; Streptococcus; Immunoglobulin G; Neisseria gonorrhoeae; Effector","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457537,0.0002356215,0.00009852962,0.0001480391,0.00007353297,0.0002274739,0.0001706707,0.0002065575,0.001658499],"category_scores_gemma":[0.0001189616,0.00005490289,0.0001584033,0.00007337292,0.0001589906,0.0000829029,0.0001585299,0.0003821984,0.0002173987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898204,"about_ca_system_score_gemma":0.000110148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000313991,"about_ca_topic_score_gemma":0.0003203697,"domain_scores_codex":[0.9999014,0.00001630968,0.000005827243,0.00001703656,0.0000272332,0.00003224858],"domain_scores_gemma":[0.9999548,0.00000667989,0.00001245659,0.000008217267,0.000007455276,0.00001041936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002552811,0.00001358903,0.0001731036,0.00001397538,0.000003206943,0.0000402124,0.000006445148,0.00003347079,0.9975957,0.0001059433,0.00001989024,0.001968915],"study_design_scores_gemma":[0.000008465066,0.0002385297,0.003020783,0.00000406354,0.000009833669,0.0003209804,0.00001198491,0.0002478349,0.9934289,0.00006415141,0.002641794,0.000002647696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898139,0.001385541,0.004285194,0.0001177181,0.00004383007,0.00002948688,0.00009529827,0.0001232541,0.004105997],"genre_scores_gemma":[0.9971927,0.0003572362,0.0009548239,0.00009165608,0.000006007569,0.000006585922,0.00007908962,0.000009482389,0.001302449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658499,"threshold_uncertainty_score":0.005548239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843874188284737,"score_gpt":0.2916163009729533,"score_spread":0.2731775590901059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}