{"id":"W4415226237","doi":"10.1158/1078-0432.ccr-24-4010","title":"Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Population Health Research Institute; McMaster University Medical Centre; Hospital for Sick Children; Hamilton Health Sciences; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Medulloblastoma; Dynamics (music); Cancer; Acquired resistance; Drug resistance; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551326,0.0003108119,0.0003032601,0.0003286923,0.0001614228,0.0003871761,0.000235342,0.0002149607,0.001354122],"category_scores_gemma":[0.000234879,0.0001201504,0.0002050421,0.0001461216,0.0001628816,0.0002306395,0.0003007714,0.000647914,0.0003159091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000438929,"about_ca_system_score_gemma":0.0003202296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006946308,"about_ca_topic_score_gemma":0.002146921,"domain_scores_codex":[0.9998629,0.00001020413,0.000007685285,0.00003245893,0.000057104,0.00002971999],"domain_scores_gemma":[0.9998915,0.00001917297,0.0000339231,0.00001523494,0.00001815551,0.00002191653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008304918,0.00008321971,0.0007568369,0.00007057244,0.00001135263,0.00004561751,0.00002621538,0.0008675507,0.9846838,0.0002180451,0.0003072174,0.01284641],"study_design_scores_gemma":[0.00003196314,0.0008720678,0.005340158,0.00001277427,0.00004211432,0.0003645064,0.00004173449,0.005324132,0.9791183,0.0001362802,0.008707287,0.000008642842],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813752,0.002657629,0.01094584,0.0003035119,0.00006416134,0.0002267872,0.0006242974,0.0007003856,0.003102144],"genre_scores_gemma":[0.9917155,0.001377635,0.004587738,0.0001156384,0.00001344795,0.00008733164,0.0004290703,0.000053138,0.001620503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354122,"threshold_uncertainty_score":0.004530013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1961110470355769,"score_gpt":0.5517871050590704,"score_spread":0.3556760580234934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}