{"id":"W4415228131","doi":"10.1016/j.sbi.2025.103167","title":"Membrane protein reconstitution : New possibilities for structural biology, biophysical methods, and antibody/drug discovery","year":2025,"lang":"en","type":"editorial","venue":"Current Opinion in Structural Biology","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Biological and Environmental Research","keywords":"Membrane protein; Protein structure; Structural biology; Protein–protein interaction; Membrane; Protein stability","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005305434,0.0005827122,0.0007776353,0.0001839593,0.0001734862,0.00008088881,0.0004787325,0.001162437,0.00001293367],"category_scores_gemma":[0.00205596,0.000482514,0.000243406,0.0001582784,0.0008469525,0.00002669339,0.0003335981,0.0006720075,7.972511e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008890671,"about_ca_system_score_gemma":0.0009287932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002079553,"about_ca_topic_score_gemma":0.00003038405,"domain_scores_codex":[0.9964429,0.0006472062,0.0008145696,0.001468192,0.0001042352,0.0005228886],"domain_scores_gemma":[0.9983332,0.0003169625,0.0003730642,0.0006298501,0.0002213436,0.0001255528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003059763,0.0001069467,0.002690411,0.005397758,0.0004034883,2.894679e-7,0.0002550668,0.000007146089,0.5940396,0.04624354,0.1490276,0.1987684],"study_design_scores_gemma":[0.002204256,0.0004185221,0.000537462,0.0003627651,0.00004100697,0.00000366224,0.00005128625,0.0001323448,0.0201349,0.02975406,0.9453971,0.0009625683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.08180722,0.02981434,0.007957459,0.0004476336,0.8706553,0.003613086,0.005596024,0.00006572833,0.00004323446],"genre_scores_gemma":[0.1363603,0.01075575,0.02285676,0.00005501627,0.7193628,0.001236389,0.1074548,0.0001199842,0.001798139],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.7963696,"threshold_uncertainty_score":0.9997627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496307901047068,"score_gpt":0.4090258806647776,"score_spread":0.3840628016543069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}