{"id":"W4415229655","doi":"10.1007/s40261-025-01474-3","title":"Comparative Bioavailability of Methylphenidate Powder for Prolonged-Release Oral Suspension and Methylphenidate Prolonged-Release Chewable Tablets versus Methylphenidate Immediate-Release Tablets: Phase 1, Single-Dose, Randomised, Crossover Studies in Healthy Adults","year":2025,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharma Medica Research (Canada)","funders":"Neuraxpharm","keywords":"Bioequivalence; Methylphenidate; Crossover study; Bioavailability; Suspension (topology); Drug; Dosage form","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003578648,0.00161668,0.004326292,0.0006740151,0.000460784,0.0009524316,0.001044721,0.002669181,0.004350632],"category_scores_gemma":[0.00394727,0.001516751,0.002171468,0.0004718433,0.001397936,0.001882901,0.0006059795,0.002136296,0.0006940432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005727357,"about_ca_system_score_gemma":0.001074994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006788909,"about_ca_topic_score_gemma":0.00110715,"domain_scores_codex":[0.9978833,0.001124221,0.0002354398,0.0003556537,0.0002214999,0.0001799856],"domain_scores_gemma":[0.9976411,0.0007894209,0.0006949771,0.0001860385,0.0002330254,0.0004555172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9624791,0.0128524,0.0004056603,0.0005972388,0.0006775474,0.00004054474,0.0001078924,0.00014787,0.01255738,0.00004385839,0.0001843554,0.009906184],"study_design_scores_gemma":[0.4475499,0.5432647,0.004191694,0.00002965335,0.0009079378,0.00005106044,0.00003662294,0.0003702336,0.003066559,0.0001013922,0.0003927816,0.0000373661],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932441,0.002742721,0.0004878097,0.0001358665,0.0002067764,0.002209658,0.000411093,0.00004644367,0.0005155829],"genre_scores_gemma":[0.991056,0.001952387,0.001799596,0.0002254582,0.0003661064,0.00275371,0.0004582342,0.00002268098,0.001365801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004350632,"threshold_uncertainty_score":0.01892591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.180746463865971,"score_gpt":0.4623158440696354,"score_spread":0.2815693802036645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}