{"id":"W4415229655","doi":"10.1007/s40261-025-01474-3","title":"Comparative Bioavailability of Methylphenidate Powder for Prolonged-Release Oral Suspension and Methylphenidate Prolonged-Release Chewable Tablets versus Methylphenidate Immediate-Release Tablets: Phase 1, Single-Dose, Randomised, Crossover Studies in Healthy Adults","year":2025,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharma Medica Research (Canada)","funders":"Neuraxpharm","keywords":"Bioequivalence; Methylphenidate; Crossover study; Bioavailability; Suspension (topology); Drug; Dosage form","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005382048,0.0008502988,0.00307839,0.0005776501,0.0003641533,0.00008320068,0.0002957512,0.0005431422,0.00006736079],"category_scores_gemma":[0.01645051,0.0007681487,0.0005145062,0.001498368,0.002441195,0.0009786946,0.000317621,0.001163018,0.00002767452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003839324,"about_ca_system_score_gemma":0.001105473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005777924,"about_ca_topic_score_gemma":0.0008721923,"domain_scores_codex":[0.9910139,0.002017682,0.003354043,0.001874967,0.0007391999,0.001000214],"domain_scores_gemma":[0.9879004,0.00688367,0.001557442,0.001053008,0.001855911,0.0007496086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8149461,0.01606417,0.03973515,0.008311565,0.003707225,0.00008891642,0.009084543,0.001726531,0.08402928,0.0005386738,0.006218393,0.01554953],"study_design_scores_gemma":[0.7629458,0.01269474,0.02676453,0.003964588,0.005769155,0.00002022977,0.01676728,0.05001424,0.1111488,0.004427587,0.002787293,0.002695695],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813882,0.00421023,0.0002567413,0.004749256,0.001053788,0.007862681,0.0002483856,0.0001544707,0.0000762804],"genre_scores_gemma":[0.9922678,0.000615833,0.003532669,0.001443726,0.000142392,0.000892084,0.0006798776,0.00007990954,0.0003456994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05200018,"threshold_uncertainty_score":0.999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.180746463865971,"score_gpt":0.4623158440696354,"score_spread":0.2815693802036645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}