{"id":"W4415242252","doi":"10.1038/s41598-025-20183-7","title":"CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University; McMaster University Medical Centre; Juravinski Cancer Centre","funders":"Hospital for Sick Children; University of Toronto; McMaster University; Mitacs; GlaxoSmithKline","keywords":"Glioblastoma; SOX2; CRISPR; Regulator; Stem cell; Cellular stress response","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124817,0.0002565963,0.0002603574,0.0002072937,0.0001730905,0.000277717,0.0002136232,0.0002673237,0.001599334],"category_scores_gemma":[0.0001140416,0.0001074956,0.0002121546,0.0001400981,0.0001850072,0.00007222995,0.0002184609,0.0003311135,0.0004031232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192463,"about_ca_system_score_gemma":0.0002398393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213197,"about_ca_topic_score_gemma":0.002710088,"domain_scores_codex":[0.9998854,0.00001306842,0.00001391618,0.00002759378,0.00004307447,0.00001693875],"domain_scores_gemma":[0.9999121,0.00002193785,0.00002446152,0.000009131758,0.000006960949,0.00002541653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000741316,0.00001725854,0.000401642,0.00002328269,0.000007174854,0.0003447037,0.00001238371,0.0001615339,0.9970696,0.0001596383,0.00009088105,0.001637748],"study_design_scores_gemma":[0.00003023269,0.0001849813,0.01258862,0.00001489155,0.00006125709,0.001106713,0.0000611209,0.005505649,0.9732485,0.0001768082,0.007004214,0.00001695747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983158,0.0006862425,0.01088508,0.000215895,0.00007223114,0.00004552512,0.00137854,0.0004904149,0.003068137],"genre_scores_gemma":[0.992857,0.0003183699,0.003254961,0.0001104781,0.00000745036,0.00001657803,0.0007653742,0.00005815518,0.002611562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599334,"threshold_uncertainty_score":0.005350351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007235077321012471,"score_gpt":0.2974750074704566,"score_spread":0.2902399301494442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}