{"id":"W4415243070","doi":"10.1038/s41598-025-18046-2","title":"Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in female mice","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Diet and metabolism studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Princess Takamatsu Cancer Research Fund; Ministry of Education, Culture, Sports, Science and Technology; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"Niacin; Transcriptome; Gut flora; Gene; Methionine; Nutrient sensing; Gene expression profiling; Lactobacillus; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184421,0.0005476779,0.0004525056,0.0007695782,0.0002482675,0.0004385574,0.0002604426,0.0005546377,0.001677655],"category_scores_gemma":[0.0001615977,0.0003007465,0.0004925217,0.0002605412,0.0005991968,0.0003283275,0.0003734783,0.001136644,0.0003626099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177311,"about_ca_system_score_gemma":0.0002967861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007801675,"about_ca_topic_score_gemma":0.001722712,"domain_scores_codex":[0.9997037,0.00004008021,0.00002392014,0.0001103991,0.00006295257,0.00005893545],"domain_scores_gemma":[0.9997075,0.00002331861,0.000119738,0.00002861676,0.00002166913,0.00009905937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007396746,0.00007392797,0.001034223,0.00004021729,0.00001363164,0.0000619682,0.00003209676,0.00003750602,0.9964229,0.00006348077,0.00004692381,0.001433378],"study_design_scores_gemma":[0.00009504874,0.001774996,0.06147281,0.00005232218,0.0001204339,0.000449914,0.0003153456,0.0009505324,0.9300276,0.0002702708,0.004441028,0.00002976112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919029,0.001296974,0.003485071,0.000284625,0.00005464132,0.00003182993,0.002007883,0.000132912,0.0008031949],"genre_scores_gemma":[0.9805563,0.001856281,0.005419979,0.0004384957,0.00003181885,0.0002396216,0.002307743,0.0002171214,0.008932737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677655,"threshold_uncertainty_score":0.005612314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851913424572299,"score_gpt":0.2829370398494587,"score_spread":0.2644179056037357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}