{"id":"W4415243548","doi":"10.1016/j.metop.2025.100400","title":"FDG-PET brain glucose hypometabolism predicts Alzheimer's disease progression pathways in cognitively normal adults: A longitudinal competing risks modeling","year":2025,"lang":"en","type":"article","venue":"Metabolism Open","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"","keywords":"Disease; Dementia; Diabetes mellitus; Alzheimer's disease; Biomarker; Degenerative disease; Carbohydrate metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002052813,0.000498364,0.000965753,0.0007874018,0.0003565958,0.000368907,0.0007158253,0.0001076722,0.0003400103],"category_scores_gemma":[0.0009736387,0.0004331538,0.0002182667,0.001266733,0.0001763521,0.000839513,0.001387191,0.0007696333,0.00007853372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006300013,"about_ca_system_score_gemma":0.00083732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000545023,"about_ca_topic_score_gemma":0.00003948207,"domain_scores_codex":[0.995373,0.0005756828,0.0008704495,0.001048483,0.001026581,0.001105865],"domain_scores_gemma":[0.9978188,0.0002486571,0.0001827785,0.0005083789,0.0006100548,0.0006313759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01867094,0.005186406,0.5644627,0.000718756,0.001132865,0.002963825,0.001397303,0.000224157,0.001754061,0.001920067,0.0009876604,0.4005812],"study_design_scores_gemma":[0.01669521,0.0002140279,0.9250351,0.00327297,0.001047847,0.00003173913,0.001107565,0.04657709,0.002014276,0.0008911617,0.002586397,0.0005266439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695877,0.01129793,0.001385845,0.001790034,0.0003126162,0.004593844,0.0001889861,0.0001197634,0.01072327],"genre_scores_gemma":[0.9945733,0.0004808532,0.001866129,0.001222246,0.0002808223,0.0009995274,0.0002885953,0.00005706888,0.0002314693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4000546,"threshold_uncertainty_score":0.999812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06010367978442606,"score_gpt":0.3726500057061862,"score_spread":0.3125463259217601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}