{"id":"W4415247996","doi":"10.1161/hyp.82.suppl_1.059","title":"Abstract 059: Cardiovascular injury associated with Transient Receptor Potential Melastatin 7 (TRPM7) downregulation and Mg <sup>2+</sup> deficiency involve calpain.","year":2025,"lang":"en","type":"article","venue":"Hypertension","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"TRPM7; Downregulation and upregulation; Transient receptor potential channel; Periostin; Calpastatin; TRPC1; Receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000394439,0.0002128217,0.0002405271,0.0001118294,0.000230487,0.0000534526,0.00006187231,0.0002672636,0.00001566854],"category_scores_gemma":[0.0001315372,0.0001737045,0.0001657327,0.0002184768,0.0001071502,0.00001850381,0.00004151008,0.0001249358,0.000004107782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004076591,"about_ca_system_score_gemma":0.00009005457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005295975,"about_ca_topic_score_gemma":0.00001758742,"domain_scores_codex":[0.9985864,0.0001253361,0.0002608549,0.0005014678,0.0002895717,0.0002363675],"domain_scores_gemma":[0.9992464,0.00001771822,0.00007378426,0.0003010175,0.00027329,0.00008779881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009769902,0.0003321551,0.0009300771,0.0001015657,0.0005256702,0.00001253466,0.0001462004,0.0223702,0.9198923,0.0001032203,0.01125713,0.04335198],"study_design_scores_gemma":[0.0176391,0.002895915,0.4906405,0.001388699,0.002033882,0.0001953874,0.002556876,0.07970203,0.2181652,0.0003747547,0.1812656,0.003142084],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836589,0.001435401,0.01370038,0.000340952,0.0001381041,0.0004434379,0.00002099502,0.00004492766,0.0002169249],"genre_scores_gemma":[0.9980294,0.0001561738,0.0003081725,0.0003483153,0.0000798678,0.00002551199,0.000500915,0.00002207381,0.0005296065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7017271,"threshold_uncertainty_score":0.7083465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006291314593797306,"score_gpt":0.1927391808430636,"score_spread":0.1864478662492663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}