{"id":"W4415248847","doi":"10.1038/s41375-025-02783-4","title":"OGG1 activation improves T cell resilience to oxidative stress after allo-SCT and T cell engager exposure","year":2025,"lang":"en","type":"article","venue":"Leukemia","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science for Life Laboratory; European Regional Development Fund; Deutsche Forschungsgemeinschaft; Karolinska Institutet; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Friedrich-Alexander-Universität Erlangen-Nürnberg","keywords":"T cell; Oxidative stress; Cytotoxic T cell; T lymphocyte; Resilience (materials science); Cell growth; Cell; Regulatory T cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121045,0.0001608939,0.000151617,0.0001412548,0.0001731492,0.00003405857,0.0001092255,0.0002066478,0.0004518818],"category_scores_gemma":[0.00005894096,0.0001470198,0.00004343698,0.0001477938,0.00006084199,0.0002134512,0.00009147535,0.0004032807,0.0003007053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162109,"about_ca_system_score_gemma":0.00008188345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000147311,"about_ca_topic_score_gemma":0.00001732134,"domain_scores_codex":[0.9990624,0.0001495758,0.0002060615,0.0003316414,0.00002827087,0.0002221075],"domain_scores_gemma":[0.9994593,0.0001398108,0.00007223026,0.0002351148,0.00007392326,0.00001958672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004227355,0.00004684995,0.000989666,0.00003560252,0.00002362888,0.000001032345,0.0009584441,0.00001893511,0.981078,0.00004521546,0.01280412,0.003575756],"study_design_scores_gemma":[0.0006538989,0.0001658556,0.01965643,0.00005314014,0.00001879423,0.000001486112,0.001017547,0.00000893079,0.8948059,0.00001700518,0.08346347,0.0001375458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834185,0.0006230531,0.001014892,0.0002078961,0.001377958,0.0002592947,0.000004970987,0.00005640885,0.01303704],"genre_scores_gemma":[0.9125657,0.00004453535,0.00008076302,0.001095456,0.00002142563,0.00005406349,0.00004048581,0.000008000243,0.08608954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08627212,"threshold_uncertainty_score":0.5995296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004411473820002763,"score_gpt":0.2138654921747208,"score_spread":0.209454018354718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}