{"id":"W4415250611","doi":"10.1038/s44319-025-00593-4","title":"Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death","year":2025,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Structural Genomics Consortium; Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; Hessisches Ministerium für Wissenschaft und Kunst; Deutsche Forschungsgemeinschaft","keywords":"Ubiquitin ligase; Druggability; Ubiquitin; RNF4; Covalent bond; DNA ligase; Programmed cell death; Ligand (biochemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651062,0.000362789,0.0001477116,0.00007772295,0.0000825376,0.0001386685,0.0001790903,0.000221248,0.0007384736],"category_scores_gemma":[0.0001230394,0.00008509571,0.0001665224,0.00007524886,0.0002039751,0.0001485954,0.0001754283,0.0002713274,0.0002189436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362155,"about_ca_system_score_gemma":0.000152944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002690412,"about_ca_topic_score_gemma":0.0005080894,"domain_scores_codex":[0.999866,0.0000290749,0.00001270709,0.00002626868,0.00003704093,0.00002877395],"domain_scores_gemma":[0.999881,0.00002234916,0.0000491617,0.00001681285,0.00001482384,0.00001595648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004495255,0.00001409766,0.0001064257,0.00002719174,0.000004337028,0.00003466152,0.000005497303,0.00006770073,0.9986619,0.00009282939,0.00002138777,0.0009190119],"study_design_scores_gemma":[0.000004635911,0.00008729355,0.0003459659,0.000001108075,0.000002239385,0.00008604417,0.000002692174,0.0001349378,0.9984767,0.00001054473,0.0008464861,0.000001272647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884148,0.001202535,0.007867367,0.0000891794,0.00001671893,0.00006366992,0.0001299204,0.00009589842,0.002119983],"genre_scores_gemma":[0.9928351,0.0006649221,0.004036,0.00004228866,0.000004421962,0.00003803369,0.0001812894,0.0000126751,0.002185361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007384736,"threshold_uncertainty_score":0.002470434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008257425798508243,"score_gpt":0.2478966417882908,"score_spread":0.2396392159897826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}