{"id":"W4415258664","doi":"10.1016/j.omtn.2025.102744","title":"Innovative aptamer approaches in glial tumor diagnostics and therapy: Progress and future directions","year":2025,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ministry of Health of the Russian Federation; Russian Science Foundation","keywords":"Aptamer; Liquid biopsy; Drug delivery; Glioblastoma; Targeted drug delivery; Nucleic acid; Cancer; Cancer treatment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004844087,0.0006320641,0.001265914,0.0003799967,0.0001604213,0.0002283004,0.0003673778,0.0003039722,0.00005218162],"category_scores_gemma":[0.00006806487,0.0005039875,0.00013857,0.001317052,0.0004800736,0.0001499908,0.0001837971,0.0004413934,0.00001571012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000887686,"about_ca_system_score_gemma":0.0002978491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002007768,"about_ca_topic_score_gemma":0.000003739478,"domain_scores_codex":[0.9971426,0.0005816931,0.0006107397,0.0008744416,0.0003129182,0.0004775981],"domain_scores_gemma":[0.9987427,0.0002313504,0.0002746482,0.000540265,0.000106663,0.0001043898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000630139,0.0002497172,0.0001070917,0.001092196,0.00009777529,0.0001077726,0.000360355,4.146308e-7,0.0008523826,0.0005347987,0.0000533403,0.9964811],"study_design_scores_gemma":[0.001261875,0.0002461503,0.0001067569,0.002192254,0.0001192264,0.00004120935,0.0001114001,0.00001371752,0.003702555,0.0001675274,0.9912637,0.0007735586],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0680435,0.9294046,0.00002828926,0.0001995937,0.0004202324,0.001616208,0.00009467315,0.0001069405,0.00008597134],"genre_scores_gemma":[0.001321818,0.9964674,0.0009476878,0.0002980894,0.0002066949,0.000602774,0.00003438611,0.00008956849,0.00003159441],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9957076,"threshold_uncertainty_score":0.9997412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718208048444502,"score_gpt":0.2796564511271745,"score_spread":0.2524743706427295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}