{"id":"W4415260735","doi":"10.1093/ndt/gfaf216","title":"Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science","keywords":"Nephropathy; Pathogenesis; TLR9; Glomerulonephritis; Secretory IgA; Immunoglobulin A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810202,0.0002494508,0.0002682556,0.0002684877,0.0001728804,0.0003095283,0.000154817,0.0004351786,0.0009515351],"category_scores_gemma":[0.000209556,0.00008142252,0.0002147974,0.0001506903,0.0002395644,0.0001989851,0.0003240652,0.0005128664,0.0001844272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843091,"about_ca_system_score_gemma":0.0001778058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000266498,"about_ca_topic_score_gemma":0.0002687174,"domain_scores_codex":[0.9998791,0.00002572335,0.00001065618,0.00002694712,0.0000239383,0.00003365109],"domain_scores_gemma":[0.9999061,0.00001201235,0.00002518806,0.00000638452,0.00001706075,0.00003333711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001125923,0.000128667,0.0148117,0.0002341822,0.0000169341,0.0004607631,0.0001138582,0.000122187,0.9727969,0.0001019637,0.0001367391,0.009950131],"study_design_scores_gemma":[0.0005996424,0.003717887,0.4224705,0.0001617767,0.0003848486,0.004765124,0.001444647,0.005403721,0.53897,0.001101227,0.02094153,0.00003915869],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949797,0.003188553,0.0006697598,0.000119343,0.00004424999,0.00003809182,0.0000872101,0.00003295224,0.0008400974],"genre_scores_gemma":[0.9978861,0.0008292216,0.0006538997,0.00009412998,0.00004024279,0.00002287989,0.00006387371,0.000004041515,0.0004056037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009515351,"threshold_uncertainty_score":0.003183186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007167048773403316,"score_gpt":0.245714503743381,"score_spread":0.2385474549699777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}