{"id":"W4415262455","doi":"10.1161/hyp.82.suppl_1.027","title":"Abstract 027: Vascular Smooth Muscle Cell Plasticity in Human Hypertension Is Defined by a Distinct Oxidative Proteome and Downregulation of Nox5-Targeting miRNAs","year":2025,"lang":"en","type":"article","venue":"Hypertension","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Downregulation and upregulation; Vascular smooth muscle; microRNA; Proteome; Oxidative stress; Vascular remodelling in the embryo; Proteomics; NOX1; Angiotensin II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737465,0.0002432888,0.0003020185,0.0002137355,0.0002277471,0.0003946665,0.0001293535,0.0002971219,0.00563352],"category_scores_gemma":[0.0001497192,0.0001315008,0.0002718056,0.0001996829,0.0001843218,0.0002140926,0.000223025,0.0005193158,0.0009368668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584814,"about_ca_system_score_gemma":0.0001651533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000484446,"about_ca_topic_score_gemma":0.0003840134,"domain_scores_codex":[0.9998073,0.00002526366,0.00001595177,0.0000651253,0.00005579122,0.00003063279],"domain_scores_gemma":[0.9998937,0.000009338586,0.00002524633,0.000008697973,0.00002568453,0.00003737426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004868057,0.00003941177,0.002691246,0.000113878,0.0000177439,0.0001808836,0.00005141817,0.00001253218,0.9909111,0.00007438054,0.0002482261,0.005172394],"study_design_scores_gemma":[0.00006684044,0.001075014,0.3106219,0.00004328403,0.0001634046,0.002947731,0.0002477972,0.0008257861,0.6720709,0.000325254,0.01159379,0.00001829688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866294,0.003160731,0.004621851,0.0004776987,0.0001917143,0.00003610797,0.00208641,0.0001635309,0.002632641],"genre_scores_gemma":[0.9866758,0.001498706,0.00199644,0.0002751049,0.0001267743,0.00005678405,0.001927526,0.00004854224,0.0073943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00563352,"threshold_uncertainty_score":0.01884604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089335863929954,"score_gpt":0.2225475742347898,"score_spread":0.2116542155954902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}