{"id":"W4415263628","doi":"10.1038/s41420-025-02745-w","title":"Evidence of fructose metabolism in colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Associazione Italiana per la Ricerca sul Cancro; National Natural Science Foundation of China; European Commission","keywords":"Colorectal cancer; Metabolomics; Glycolysis; Fructose; Warburg effect; Metabolic pathway; Metabolism; Carbohydrate metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267905,0.0001461431,0.0002524094,0.00008448853,0.00002651725,0.00002102447,0.0002142083,0.0001204916,0.0000218574],"category_scores_gemma":[0.00006696191,0.0001387531,0.0001228736,0.000184788,0.00007021266,0.00001677507,0.0001349703,0.0000909454,0.000001944567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001970871,"about_ca_system_score_gemma":0.0003617764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004443958,"about_ca_topic_score_gemma":0.000383811,"domain_scores_codex":[0.999048,0.00004884726,0.0002405794,0.000329589,0.0001051921,0.0002277862],"domain_scores_gemma":[0.9995589,0.00002289091,0.00007684196,0.0002503913,0.00005179648,0.00003918378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002475423,0.00007290105,0.01019576,0.0001013243,0.00003040152,9.441248e-7,0.000056113,0.0001341757,0.9848309,0.0003996275,0.001724371,0.002205927],"study_design_scores_gemma":[0.0006546181,0.0000344152,0.07301586,0.0001413785,0.00005690068,8.733244e-7,0.00005301032,0.00001453091,0.8989875,0.0001653326,0.02671715,0.0001583687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8988948,0.09675924,0.0002367551,0.00004604963,0.001406846,0.0001710025,0.00003393064,0.000004638554,0.00244671],"genre_scores_gemma":[0.9769637,0.01891863,0.0001164535,0.0002201444,0.0003853983,0.00005848922,0.00001511085,0.0000122607,0.003309787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08584335,"threshold_uncertainty_score":0.5658187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270233416609298,"score_gpt":0.2736420699959854,"score_spread":0.2609397358298924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}