{"id":"W4415266583","doi":"10.2218/gtopdb/f80/2025.3","title":"Voltage-gated calcium channels (Ca&lt;sub&gt;V&lt;/sub&gt;) in GtoPdb v.2025.3","year":2025,"lang":"","type":"article","venue":"IUPHAR/BPS Guide to Pharmacology CITE","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protein subunit; Gating; Linker; Transmembrane protein; Transmembrane domain; Transmembrane channels; Ion channel; Voltage-dependent calcium channel; Voltage-gated ion channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.002013115,0.001709183,0.001759325,0.001417111,0.0005816923,0.0002692965,0.002744049,0.002336805,0.001479805],"category_scores_gemma":[0.0005391975,0.001924328,0.0007419945,0.00338649,0.001255495,0.00009796733,0.00233048,0.001782599,0.001152303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006563765,"about_ca_system_score_gemma":0.002245468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001884241,"about_ca_topic_score_gemma":0.0002531626,"domain_scores_codex":[0.9884944,0.0007468881,0.002545586,0.00341993,0.0008749581,0.003918222],"domain_scores_gemma":[0.9951659,0.000233162,0.0004816751,0.001566261,0.001253848,0.001299172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070155,0.0008267099,0.002132539,0.0004054857,0.0005542208,0.0003565178,0.000122393,0.000110667,0.6828629,0.00003698647,0.3032193,0.008302136],"study_design_scores_gemma":[0.00374729,0.0003838683,0.0004236623,0.0002543417,0.0002510605,0.00003529929,0.00008171365,0.0008660434,0.6014829,0.0000221237,0.3913586,0.001093111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473389,0.01741791,0.002007648,0.01104148,0.006958243,0.00406221,0.0008021972,0.0001639144,0.0102075],"genre_scores_gemma":[0.9487745,0.009108004,0.0001242372,0.01096855,0.002146914,0.0007608401,0.0009370001,0.0001609009,0.02701906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08813933,"threshold_uncertainty_score":0.9996254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797685431546863,"score_gpt":0.3526639026180405,"score_spread":0.3346870483025719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}