{"id":"W4415275384","doi":"10.17615/zg2n-en48","title":"Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria","year":2025,"lang":"","type":"article","venue":"UNC Libraries","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Health and Medical Research Council; New South Wales Government; Honjo International Scholarship Foundation; Fonds National de la Recherche Luxembourg; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Australian Government; Agence Nationale de la Recherche; Fondation du Souffle; McGill University; Deutsche Forschungsgemeinschaft; Sidra Medicine; Institut des maladies génétiques Imagine; Canadian Institutes of Health Research; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Compute Canada; Qatar National Research Fund; Fondation pour la Recherche Médicale; Immune Deficiency Foundation; St. Giles Foundation; European Commission; Sidaction; Yale University; Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health","keywords":"Immunity; IRF1; Innate immune system; Acquired immune system; Humoral immunity; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000567701,0.0008045353,0.001243438,0.0007032351,0.001044484,0.001415938,0.001172586,0.0004876553,0.02052737],"category_scores_gemma":[0.002035981,0.0007663529,0.0004053853,0.001899633,0.0006361413,0.001137439,0.001943648,0.001149288,0.002308895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003674662,"about_ca_system_score_gemma":0.001700905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654451,"about_ca_topic_score_gemma":0.0001510299,"domain_scores_codex":[0.9947141,0.0005080385,0.001091342,0.001019542,0.0008988109,0.001768142],"domain_scores_gemma":[0.9954556,0.0007164238,0.0001905085,0.002028571,0.0003105568,0.001298328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002282024,0.001620732,0.127553,0.002345307,0.001203031,0.0004437378,0.002569874,0.00000208364,0.06100501,0.3387143,0.4550062,0.007254648],"study_design_scores_gemma":[0.004017598,0.001933087,0.5923681,0.00218927,0.0004997199,0.00001202564,0.001490242,0.00001823822,0.08013744,0.02962142,0.2867202,0.0009926503],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8428547,0.005841109,0.0001757916,0.01473967,0.002808029,0.001896728,0.0006785552,0.0003300597,0.1306753],"genre_scores_gemma":[0.9102477,0.0002693256,0.001659509,0.006923227,0.001217775,0.0001901296,0.0002771411,0.00009925848,0.07911596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4648151,"threshold_uncertainty_score":0.9996207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848699751358741,"score_gpt":0.3124981925028215,"score_spread":0.2940111949892341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}