{"id":"W4415278307","doi":"10.1016/j.trechm.2025.09.001","title":"Non-carbohydrate syntheses of nucleoside analogues","year":2025,"lang":"en","type":"article","venue":"Trends in Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Nucleoside; Oligonucleotide; Drug; Oligonucleotide synthesis; Process (computing); Drug discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359769,0.0006124554,0.0003822033,0.0003421116,0.0003494746,0.0005478591,0.0005458593,0.0003681173,0.004135244],"category_scores_gemma":[0.000381801,0.0001768682,0.0003783914,0.0004405867,0.0002578284,0.0006162972,0.0005653676,0.001032749,0.001670475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006055148,"about_ca_system_score_gemma":0.000742775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008329771,"about_ca_topic_score_gemma":0.00188356,"domain_scores_codex":[0.9998215,0.0000390958,0.00001599972,0.00002948192,0.00003941003,0.00005450542],"domain_scores_gemma":[0.9998444,0.00004173109,0.00001898996,0.00002595619,0.00002977448,0.00003907344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006968219,0.0004703148,0.0004072554,0.001760626,0.0001048065,0.002708772,0.000807247,0.003238981,0.8242701,0.03287062,0.004609875,0.1280545],"study_design_scores_gemma":[0.00009188696,0.0008208053,0.0008199979,0.0001256984,0.00005966433,0.000782221,0.0001245372,0.0009597344,0.9163827,0.003613986,0.07617096,0.00004785439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6752841,0.03934292,0.05586299,0.001152432,0.002285922,0.0006791322,0.002844251,0.0003839998,0.2221643],"genre_scores_gemma":[0.9138643,0.02526228,0.02482399,0.0004449664,0.0002247684,0.0003029936,0.001707732,0.0001674658,0.03320159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004135244,"threshold_uncertainty_score":0.01383382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163900968011547,"score_gpt":0.2640198065626394,"score_spread":0.2476297097614847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}