{"id":"W4415279767","doi":"10.1016/j.jaad.2025.10.042","title":"Response to Veenstra et al’s “Benzoyl peroxide acne treatment shows no significant association with benzene-related cancers: A multicenter retrospective analysis” on statistical design","year":2025,"lang":"en","type":"letter","venue":"Journal of the American Academy of Dermatology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Multicenter study; Retrospective cohort study; Acne; Statistical analysis; Double blind study; MEDLINE; Association (psychology); Severity of illness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00831535,0.0006415454,0.001483386,0.001239709,0.002200793,0.002847518,0.001596852,0.0176982,0.004730612],"category_scores_gemma":[0.0482373,0.0006015294,0.001134886,0.001492817,0.001302634,0.00157552,0.0009168267,0.01333433,0.003991044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003104466,"about_ca_system_score_gemma":0.002364873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003678481,"about_ca_topic_score_gemma":0.006716579,"domain_scores_codex":[0.99258,0.002622073,0.001566049,0.0009174686,0.001529786,0.000784599],"domain_scores_gemma":[0.9683996,0.01794832,0.002915841,0.0012943,0.007143561,0.002298341],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007146693,0.0002055758,0.01877187,0.0001195561,0.000194111,0.006468009,0.0003182439,0.0002045918,0.0007694701,0.00128382,0.95088,0.02007014],"study_design_scores_gemma":[0.001352517,0.001077486,0.02966404,0.0009436228,0.0006917565,0.01794689,0.002858915,0.004473104,0.002689454,0.01371381,0.9242714,0.0003170103],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00371292,0.0003491788,0.0003124343,0.9773374,0.01634333,0.00005152573,0.0003295582,0.00004200613,0.001521593],"genre_scores_gemma":[0.01787791,0.0004250551,0.0006595243,0.9413908,0.03578574,0.000109165,0.0001624258,0.00004296556,0.003546496],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9916847,"threshold_uncertainty_score":0.04397631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009163806686486888,"score_gpt":0.2883420320222829,"score_spread":0.2791782253357961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}