{"id":"W4415288870","doi":"10.1016/j.ceb.2025.102593","title":"Actin cytoskeleton protection by the formin-mediated safety valve","year":2025,"lang":"en","type":"review","venue":"Current Opinion in Cell Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mechanotransduction; Cytoskeleton; Actin; Actin cytoskeleton; Function (biology); Mechanosensitive channels; Signalling; Cell; Formins","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003291356,0.0004019042,0.000619965,0.0001563878,0.0001278864,0.0000220754,0.0004352387,0.0006746273,0.00005694431],"category_scores_gemma":[0.0001666739,0.0002870583,0.0005546525,0.0003005743,0.00005739486,0.00000357338,0.0002663193,0.0007195836,0.00005303473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009826876,"about_ca_system_score_gemma":0.0003077955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003097349,"about_ca_topic_score_gemma":0.000009127478,"domain_scores_codex":[0.9978465,0.0004114342,0.0006601534,0.0006526239,0.00007245673,0.0003568203],"domain_scores_gemma":[0.998858,0.0001093212,0.0003914345,0.0005267704,0.00005989022,0.00005456038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002408254,0.0001592204,0.000001557461,0.004463096,0.00006943298,7.062589e-8,0.000008559096,7.18861e-7,0.002609887,0.0001058971,0.01622339,0.9763341],"study_design_scores_gemma":[0.0002411576,0.0001650701,2.613583e-7,0.00158493,0.00005573484,0.00000656984,0.00001173571,0.00002012821,0.0006066647,0.00003082898,0.996998,0.0002789184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000007602792,0.9877887,0.002045201,0.00005779643,0.007629045,0.001346982,0.0003539269,0.00001537659,0.0007553846],"genre_scores_gemma":[0.00006103466,0.9887679,0.000009049926,0.00001964556,0.0005315714,0.00051506,0.009471012,0.00002926924,0.0005954426],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9807746,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04497536494954327,"score_gpt":0.3595141404518979,"score_spread":0.3145387755023546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}