{"id":"W4415289836","doi":"10.1101/2025.10.17.682994","title":"GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"European Commission; Deutsches Krebsforschungszentrum","keywords":"Epigenetics; Breast cancer; Aromatase; Estrogen receptor; Gene knockdown; Estrogen; Downregulation and upregulation; Estrogen receptor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007688429,0.0001601517,0.0001344419,0.0002723973,0.0001205957,0.000240951,0.00008139,0.000236705,0.001925478],"category_scores_gemma":[0.00009757573,0.00009337343,0.0001495552,0.0002023117,0.0001397709,0.00006840688,0.0001321083,0.0002808304,0.0003736968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866316,"about_ca_system_score_gemma":0.0000722374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004013735,"about_ca_topic_score_gemma":0.0004620236,"domain_scores_codex":[0.9999624,0.000004991754,0.00000237606,0.00001346041,0.000009306032,0.000007356525],"domain_scores_gemma":[0.9998885,0.00001082638,0.00006169199,0.000006843209,0.000007289902,0.00002475164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001112981,0.00002912169,0.02441977,0.00009106088,0.00003884182,0.0004444107,0.00004083185,0.0001536773,0.9682776,0.0001157577,0.0005419431,0.004734013],"study_design_scores_gemma":[0.0001080786,0.0005975735,0.5752836,0.00002890115,0.0001507614,0.005741635,0.0002771655,0.002882994,0.4050354,0.0004524791,0.009417498,0.00002388978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956827,0.001485072,0.0008024122,0.0002916052,0.00001833349,0.000006687109,0.001057455,0.0000630751,0.0005927437],"genre_scores_gemma":[0.9964889,0.0004604695,0.0004402674,0.00009125799,0.00001102886,0.00001044267,0.001105933,0.00001250728,0.001379186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925478,"threshold_uncertainty_score":0.006441355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006603950211822748,"score_gpt":0.2129686654805768,"score_spread":0.2063647152687541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}