{"id":"W4415294110","doi":"10.1007/s12094-025-04073-y","title":"Circulating tumor DNA as a predictive biomarker for colorectal cancer postsurgical recurrence: a systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Clinical & Translational Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Università degli Studi della Campania Luigi Vanvitelli","keywords":"Colorectal cancer; Biomarker; Circulating tumor DNA; Adjuvant chemotherapy; Predictive value; Chemotherapy; Circulating tumor cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01056217,0.002322357,0.01707084,0.007412045,0.0005421671,0.002787453,0.001930538,0.001699791,0.002634462],"category_scores_gemma":[0.02356081,0.001143559,0.02995025,0.008696051,0.000629129,0.001448326,0.001229377,0.001244892,0.0002615866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001973058,"about_ca_system_score_gemma":0.003664741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006500503,"about_ca_topic_score_gemma":0.01559231,"domain_scores_codex":[0.9936507,0.00272975,0.001899099,0.0007911224,0.0006997492,0.0002295084],"domain_scores_gemma":[0.9826785,0.01251084,0.002668844,0.0005312076,0.001352029,0.0002583897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001348242,0.00002578723,0.006988817,0.3828506,0.5953128,0.0001156774,0.0000751647,0.0005894889,0.0002621853,0.00009063681,0.0005730545,0.01176748],"study_design_scores_gemma":[0.0002174756,0.0001646624,0.004901892,0.0202476,0.9729955,0.00007810709,0.00003625486,0.0001965872,0.0000977069,0.0001035673,0.0009409761,0.00001977022],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00590614,0.9925609,0.0004355044,0.0001603155,0.00009885647,0.0001867901,0.0004916319,0.00001951239,0.0001402633],"genre_scores_gemma":[0.1982643,0.7964346,0.002026784,0.0007016789,0.000257075,0.0009715594,0.001034372,0.00002752894,0.0002820397],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01707084,"threshold_uncertainty_score":0.05585873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184913492689039,"score_gpt":0.4763585150838557,"score_spread":0.3578671658149518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}