{"id":"W4415294570","doi":"10.1096/fj.202403170rr","title":"Cell‐ <scp>ELISA</scp> ‐Based High‐Throughput Screening Leads to the Discovery of Androgen Receptor Degraders to Conquer Castration‐Resistant Prostate Cancer","year":2025,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chinese Academy of Medical Sciences; Jinhua Science and Technology Bureau; Zhejiang Normal University; National Natural Science Foundation of China; McGill University","keywords":"Androgen receptor; Prostate cancer; Antiandrogen; Dihydrotestosterone; Androgen; Receptor; Testosterone (patch); Androgen Receptor Antagonists; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006098525,0.0008282867,0.0008015522,0.0007324876,0.0003201166,0.0006827661,0.0005262265,0.000437019,0.001527458],"category_scores_gemma":[0.0003576945,0.0002200799,0.0006677099,0.0008241416,0.0002985479,0.0003671784,0.0003538246,0.0008412484,0.001249532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004938182,"about_ca_system_score_gemma":0.0005678047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008452124,"about_ca_topic_score_gemma":0.002107009,"domain_scores_codex":[0.9994773,0.00009349528,0.0000410266,0.00007136704,0.000251212,0.00006574614],"domain_scores_gemma":[0.9997999,0.00003895049,0.00005109039,0.00002807008,0.00005592052,0.00002608594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002029895,0.0002313274,0.0009833586,0.0002331571,0.00005117422,0.0001887841,0.00001495443,0.001225591,0.9799488,0.0003764681,0.0009955538,0.01554777],"study_design_scores_gemma":[0.0000355181,0.0006719706,0.001872054,0.00001325915,0.0000612147,0.0003434932,0.00002423575,0.003016057,0.9860816,0.0001328238,0.007732273,0.00001554027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8541714,0.0225739,0.09421574,0.00143199,0.0002477143,0.001044847,0.01249801,0.002045399,0.01177091],"genre_scores_gemma":[0.9203361,0.01522144,0.04532636,0.0003964914,0.00007347221,0.0003159604,0.01031499,0.0001386204,0.007876541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527458,"threshold_uncertainty_score":0.005109847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02951958288438704,"score_gpt":0.3110914861465858,"score_spread":0.2815719032621988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}