{"id":"W4415297453","doi":"10.1016/s0140-6736(25)01897-5","title":"Durvalumab in combination with BCG for BCG-naive, high-risk, non-muscle-invasive bladder cancer (POTOMAC): final analysis of a randomised, open-label, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"AstraZeneca","keywords":"Durvalumab; Bladder cancer; BCG vaccine; Phase (matter); Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001749507,0.001291877,0.003103489,0.0003161348,0.0002819905,0.0010666,0.0009157084,0.001302829,0.004823267],"category_scores_gemma":[0.001544446,0.0005019248,0.002894885,0.000393965,0.0008462935,0.001088397,0.0004162486,0.003442788,0.0008948263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009729373,"about_ca_system_score_gemma":0.0009840718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001529116,"about_ca_topic_score_gemma":0.004886683,"domain_scores_codex":[0.9994123,0.0003182198,0.00002585871,0.00008771917,0.00003974488,0.0001161418],"domain_scores_gemma":[0.999312,0.0002502062,0.000126368,0.00005748995,0.00003667375,0.0002171842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9570006,0.002186327,0.0006764049,0.001383538,0.002339751,0.00006672032,0.00007723382,0.0005913763,0.002679247,0.0001889377,0.001617,0.03119281],"study_design_scores_gemma":[0.9582415,0.03737266,0.001814803,0.00006470702,0.0008610116,0.00006292114,0.00002918009,0.000332188,0.0002667807,0.0001795735,0.0007589688,0.00001572707],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746753,0.01715501,0.0007886873,0.001070484,0.0007824198,0.001419173,0.001466343,0.0001639591,0.002478633],"genre_scores_gemma":[0.9854023,0.005948587,0.001278584,0.001122945,0.0003191026,0.001176287,0.001538303,0.00003845554,0.003175437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004823267,"threshold_uncertainty_score":0.01613545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05291830162122361,"score_gpt":0.3758480207612278,"score_spread":0.3229297191400041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}