{"id":"W4415303395","doi":"10.3389/fncel.2025.1646883","title":"Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health","keywords":"Environmental enrichment; Hippocampal formation; Dentate gyrus; Hippocampus; Cognition; Recall; Cognitive decline; Excitatory postsynaptic potential; Spatial memory","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004848357,0.001710684,0.0008979547,0.001491237,0.0005217206,0.000545351,0.0009466864,0.001161656,0.002552755],"category_scores_gemma":[0.0001838598,0.0005424946,0.001112836,0.0004607991,0.0009146224,0.0006490802,0.0006564123,0.002675226,0.0005865647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000624224,"about_ca_system_score_gemma":0.0005534629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639965,"about_ca_topic_score_gemma":0.003656477,"domain_scores_codex":[0.9995883,0.00004454416,0.00005396355,0.0001117331,0.00007520043,0.0001262718],"domain_scores_gemma":[0.9994525,0.00002333513,0.0001921178,0.00004728495,0.00004680574,0.0002379859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001782819,0.001108445,0.001463844,0.0002013926,0.000072358,0.0003445659,0.000151795,0.0002668883,0.9901304,0.0003170021,0.0004063598,0.003754252],"study_design_scores_gemma":[0.0008987494,0.01285015,0.06020597,0.000385632,0.0005905559,0.001563311,0.0007099629,0.004451985,0.9065197,0.001397836,0.01031178,0.0001142591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903864,0.00147887,0.003953934,0.000518807,0.0001352686,0.00009819866,0.002068224,0.0003932594,0.0009670371],"genre_scores_gemma":[0.9709514,0.003075192,0.009268717,0.0005552353,0.00006697189,0.000893823,0.003094814,0.0002069933,0.01188679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552755,"threshold_uncertainty_score":0.008539796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181982120897191,"score_gpt":0.2633184547260497,"score_spread":0.2414986335170778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}