{"id":"W4415303395","doi":"10.3389/fncel.2025.1646883","title":"Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health","keywords":"Environmental enrichment; Hippocampal formation; Dentate gyrus; Hippocampus; Cognition; Recall; Cognitive decline; Excitatory postsynaptic potential; Spatial memory","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001716421,0.0002598588,0.0003457773,0.0004376818,0.0001920917,0.000133818,0.000420743,0.00008984782,0.000001071097],"category_scores_gemma":[0.001554164,0.0002684725,0.00006956373,0.0005032499,0.0005133486,0.0002836867,0.0002248184,0.0002710377,4.857671e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009780101,"about_ca_system_score_gemma":0.0002212281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853747,"about_ca_topic_score_gemma":0.00008001082,"domain_scores_codex":[0.9974095,0.0001973645,0.0003603444,0.001097321,0.0003174105,0.0006180219],"domain_scores_gemma":[0.9990885,0.000341302,0.0001208056,0.0002712121,0.00002912497,0.0001491032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001143154,0.0004401181,0.04145397,0.0001329659,0.000005329193,0.00009333812,0.0009555789,0.004676122,0.9306271,0.0002366162,0.00005990115,0.02017581],"study_design_scores_gemma":[0.001539288,0.00020697,0.01677773,0.00006593867,0.00001290481,0.000001328505,0.0003015547,0.7179651,0.2622387,0.0006203153,0.000007298682,0.0002628003],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7834046,0.0001460058,0.2144741,0.0001290314,0.0007646509,0.0009185261,0.00007377959,0.00003228522,0.00005701858],"genre_scores_gemma":[0.9977405,0.0001922329,0.0003070052,0.0009813592,0.00001568236,0.000221161,0.000001152803,0.00001773603,0.0005231485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.713289,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181982120897191,"score_gpt":0.2633184547260497,"score_spread":0.2414986335170778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}