{"id":"W4415305237","doi":"10.1016/j.nbd.2025.107149","title":"White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy","year":2025,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Tauopathy; White matter; Grey matter; Corpus callosum; Oligodendrocyte; Myelin; Tau pathology; Tau protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542869,0.001218312,0.0007041486,0.001780489,0.0004304654,0.0005450477,0.0005808801,0.0008958823,0.001766755],"category_scores_gemma":[0.0003532853,0.0005917041,0.0005980531,0.0004297729,0.0007430777,0.0006436709,0.0005705416,0.001529766,0.0007092836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000886121,"about_ca_system_score_gemma":0.000705165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005317362,"about_ca_topic_score_gemma":0.0107702,"domain_scores_codex":[0.9996414,0.00003170423,0.00004265847,0.0001089701,0.00006620395,0.0001090344],"domain_scores_gemma":[0.9991485,0.00004527915,0.0003706552,0.00007477539,0.00009027241,0.0002704473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001509109,0.0005379215,0.001573232,0.00008324918,0.00004117849,0.0004452212,0.0002015858,0.00009260567,0.9921563,0.0001464703,0.0001406368,0.003072607],"study_design_scores_gemma":[0.0002371631,0.01428599,0.09016269,0.0001049697,0.0002590142,0.001544147,0.0007168993,0.002460228,0.8867601,0.0006720893,0.002705249,0.00009136253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995545,0.00097128,0.001473579,0.0001556885,0.00007451502,0.00006282787,0.0005742919,0.0002591389,0.0008835673],"genre_scores_gemma":[0.9891701,0.001119706,0.003037496,0.0001784793,0.00002313033,0.0001593788,0.000716594,0.00007238847,0.005522741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005317362,"threshold_uncertainty_score":0.01057279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573065639936449,"score_gpt":0.2857094095708812,"score_spread":0.2699787531715167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}