{"id":"W4415349381","doi":"10.1038/s41591-025-04014-w","title":"Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"U.S. Department of Defense","keywords":"Multiple sclerosis; Pathophysiology; Myelin basic protein; Biomarker; Myelin; Autoantibody; Central nervous system; Proteome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009628646,0.0003287279,0.0008353437,0.0008931593,0.0001454046,0.00001693025,0.0001873734,0.0004150528,0.0001258761],"category_scores_gemma":[0.007200713,0.0002369629,0.00006854584,0.001082678,0.000606071,0.00009284468,0.0002433953,0.001500848,0.00001219112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025471,"about_ca_system_score_gemma":0.0001623511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001559475,"about_ca_topic_score_gemma":0.0002528561,"domain_scores_codex":[0.9974373,0.0001507949,0.0005804988,0.0005562154,0.000750456,0.0005247429],"domain_scores_gemma":[0.9980243,0.0009729622,0.00008474151,0.0004596443,0.0002303092,0.0002280554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001817033,0.0003918913,0.7240357,0.001402495,0.0003298424,0.00002857042,0.0009129065,0.000001255925,0.07346492,0.0002364404,0.09047101,0.106908],"study_design_scores_gemma":[0.005148956,0.0005276,0.9732155,0.005142932,0.0001046447,0.000009523565,0.0006060901,0.0009546051,0.006127206,0.0002216796,0.007739617,0.0002016615],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631146,0.009062647,0.00002888462,0.02304377,0.0004094283,0.001177316,0.00004926715,0.0001200916,0.002994017],"genre_scores_gemma":[0.9915233,0.003282574,0.0007756157,0.002908448,0.0002747634,0.0001429173,0.00004846608,0.00002553463,0.001018347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2491798,"threshold_uncertainty_score":0.9663068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03402258565015907,"score_gpt":0.3411530893662335,"score_spread":0.3071305037160744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}