{"id":"W4415351736","doi":"10.31635/ccschem.025.202506256","title":"Towards the Last Piece of the Adenosine Aptamer Puzzle: A Two-Site Cooperative RNA Aptamer","year":2025,"lang":"en","type":"article","venue":"CCS Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; Adenosine; RNA; Nucleic acid; Oligonucleotide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036073,0.0002059796,0.0001931215,0.000009921026,0.0001752811,0.00003025857,0.0005689562,0.0001720849,0.0001294684],"category_scores_gemma":[0.0002145019,0.0001255123,0.0001644487,0.0002029893,0.0002607033,0.000003254168,0.0003098329,0.0001724443,0.000008331635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001582084,"about_ca_system_score_gemma":0.0001648023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001929688,"about_ca_topic_score_gemma":0.00001029808,"domain_scores_codex":[0.9989609,0.00007190621,0.0002426666,0.0003284169,0.0001714911,0.000224608],"domain_scores_gemma":[0.998885,0.0000270065,0.0001269291,0.0007667976,0.0001507553,0.000043517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004625447,0.00004649355,0.0001296436,0.00004544967,0.0000959594,8.116915e-7,0.00005057466,0.00002134576,0.9931194,0.0002189395,0.003355526,0.002869671],"study_design_scores_gemma":[0.0003918168,0.00001885925,0.0002000568,0.00006563024,0.00004810473,0.000006612713,0.0001302106,0.00002222272,0.9489902,0.00008404048,0.0499076,0.0001347015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488649,0.002816735,0.00203857,0.002275219,0.0003138498,0.0004206146,0.00007511624,0.00001981172,0.04317523],"genre_scores_gemma":[0.9856735,0.0001235469,0.0001723563,0.000641376,0.0001887567,0.00006466874,0.00002519179,0.00001946705,0.01309115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04655207,"threshold_uncertainty_score":0.5118242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008044519221533267,"score_gpt":0.2373505116068033,"score_spread":0.22930599238527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}