{"id":"W4415356957","doi":"10.1038/s41591-025-04030-w","title":"Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Jewish General Hospital; Dr. H. Bliss Murphy Cancer Centre; Lakeridge Health; Credit Valley Hospital; Hôpital Maisonneuve-Rosemont; St Joseph's Health Centre; Hôpital du Sacré-Cœur de Montréal; Grand River Hospital; Princess Margaret Cancer Centre; Saint John Regional Hospital; Southlake Regional Health Center; Cambridge Memorial Hospital; CancerCare Manitoba; Occupational Cancer Research Centre; Saskatchewan Cancer Agency; Ottawa Hospital; Santé Montérégie; Juravinski Cancer Centre; North York General Hospital; Royal Victoria Regional Health Centre; Niagara Health System","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Billi and Bernie Marcus Foundation; Government of Canada; U.S. Department of Health and Human Services; Eastern Health Foundation; Lustgarten Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Conrad N. Hilton Foundation; National Health and Medical Research Council; Virginia and D.K. Ludwig Fund for Cancer Research","keywords":"Oxaliplatin; Colorectal cancer; Circulating tumor DNA; Clinical endpoint; Chemotherapy; Adjuvant; Stage (stratigraphy); Adjuvant chemotherapy; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008857808,0.001159705,0.002052095,0.0002328761,0.0002349453,0.0009457159,0.0006051773,0.0009899442,0.004257598],"category_scores_gemma":[0.001117885,0.0003248943,0.001106459,0.0003740316,0.0008261238,0.0008818224,0.0004583208,0.002614633,0.0006566253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000882881,"about_ca_system_score_gemma":0.001033861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096905,"about_ca_topic_score_gemma":0.003103551,"domain_scores_codex":[0.9996322,0.000173371,0.00001067231,0.00007376844,0.00002841036,0.00008150531],"domain_scores_gemma":[0.9994088,0.0001721972,0.000134116,0.000047793,0.0000256663,0.0002114495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8938929,0.003976726,0.002866233,0.0008840503,0.001323043,0.00009550057,0.0001000723,0.002768476,0.007632939,0.0006257725,0.004480131,0.08135423],"study_design_scores_gemma":[0.8806818,0.1023191,0.007747031,0.0001269637,0.001201357,0.0001379146,0.00008695767,0.001762355,0.001521733,0.001137899,0.003240256,0.00003662499],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837229,0.008087709,0.001167141,0.001893108,0.0004932461,0.0006681054,0.001171482,0.0001630178,0.00263334],"genre_scores_gemma":[0.9821937,0.003623217,0.002757259,0.002791337,0.0003958799,0.001311105,0.002209038,0.00007827242,0.004640155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004257598,"threshold_uncertainty_score":0.01424307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006492347324247806,"score_gpt":0.3304041565023239,"score_spread":0.323911809178076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}