{"id":"W4415356957","doi":"10.1038/s41591-025-04030-w","title":"Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Jewish General Hospital; Dr. H. Bliss Murphy Cancer Centre; Lakeridge Health; Credit Valley Hospital; Hôpital Maisonneuve-Rosemont; St Joseph's Health Centre; Hôpital du Sacré-Cœur de Montréal; Grand River Hospital; Princess Margaret Cancer Centre; Saint John Regional Hospital; Southlake Regional Health Center; Cambridge Memorial Hospital; CancerCare Manitoba; Occupational Cancer Research Centre; Saskatchewan Cancer Agency; Ottawa Hospital; Santé Montérégie; Juravinski Cancer Centre; North York General Hospital; Royal Victoria Regional Health Centre; Niagara Health System","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Billi and Bernie Marcus Foundation; Government of Canada; U.S. Department of Health and Human Services; Eastern Health Foundation; Lustgarten Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Conrad N. Hilton Foundation; National Health and Medical Research Council; Virginia and D.K. Ludwig Fund for Cancer Research","keywords":"Oxaliplatin; Colorectal cancer; Circulating tumor DNA; Clinical endpoint; Chemotherapy; Adjuvant; Stage (stratigraphy); Adjuvant chemotherapy; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000814618,0.0002222195,0.0005838861,0.00008395658,0.00008822793,0.00001325574,0.0002757875,0.00023441,0.00003180688],"category_scores_gemma":[0.001306219,0.0001404557,0.0001256545,0.0002714408,0.0002218712,0.000002478113,0.00006571583,0.0004164132,4.544324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008230798,"about_ca_system_score_gemma":0.0003816391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021445,"about_ca_topic_score_gemma":0.0007019019,"domain_scores_codex":[0.9985087,0.0001375659,0.0005081599,0.0003904678,0.0001863892,0.0002687061],"domain_scores_gemma":[0.9989376,0.0002892232,0.0001874569,0.0003872469,0.0001428353,0.00005561807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4789703,0.000244395,0.0000633434,0.00003834534,0.0002556847,0.00005061064,0.0002836693,0.0007101429,0.4424211,0.0007771276,0.006676285,0.06950893],"study_design_scores_gemma":[0.9394054,0.0007226031,0.0000921226,0.0002439217,0.00009187046,0.000008963838,0.0001474568,0.002378375,0.02299459,0.0005387628,0.03315288,0.0002230069],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947519,0.04122745,0.0007281169,0.005700171,0.001813819,0.001892174,0.0000214403,0.00001318792,0.00108462],"genre_scores_gemma":[0.9856989,0.006310679,0.00007585719,0.006641564,0.0005569762,0.0003070706,0.0001206584,0.00001986792,0.0002684412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4604351,"threshold_uncertainty_score":0.5727617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006492347324247806,"score_gpt":0.3304041565023239,"score_spread":0.323911809178076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}