{"id":"W4415361197","doi":"10.3390/cells14201628","title":"Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Perampanel; Neuroprotection; AMPA receptor; Neurodegeneration; NMDA receptor; Glutamate receptor; Brain ischemia; Stroke (engine)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000408,0.0004322485,0.0007062848,0.0002984731,0.0001250416,0.0001807197,0.0003982151,0.0002837432,0.001249405],"category_scores_gemma":[0.0001021477,0.0001682316,0.0002913825,0.0002330667,0.0001761032,0.0003085816,0.0001516615,0.0008675651,0.0003763536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124291,"about_ca_system_score_gemma":0.0002909906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004849311,"about_ca_topic_score_gemma":0.001084612,"domain_scores_codex":[0.9998934,0.00001212224,0.00001582699,0.00001513629,0.00002528999,0.00003813816],"domain_scores_gemma":[0.9999506,0.000004037759,0.00001793464,0.000005459754,0.000007452807,0.00001447031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008399608,0.000325152,0.0001495165,0.0002791682,0.00003771871,0.0001315388,0.00002472276,0.0001679614,0.9924015,0.0001177852,0.0003328898,0.005192002],"study_design_scores_gemma":[0.000311235,0.004216062,0.003953522,0.00002797748,0.0000879771,0.0006134451,0.00004293509,0.001634836,0.9861441,0.0001269782,0.002827153,0.00001375278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880287,0.006090796,0.002317137,0.0002756677,0.00008048573,0.00007373827,0.0005323905,0.0002301309,0.002370911],"genre_scores_gemma":[0.987946,0.006100432,0.001946157,0.0001108084,0.00002686928,0.000178532,0.0008112438,0.00001582528,0.002864117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249405,"threshold_uncertainty_score":0.004179657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05129355328827706,"score_gpt":0.3486274281449424,"score_spread":0.2973338748566653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}