{"id":"W4415361591","doi":"10.1038/s41591-025-04023-9","title":"Plasma proteome adaptations during feminizing gender-affirming hormone therapy","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Sex and Gender in Healthcare","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; National Institutes of Health; Australian Government; State Government of Victoria; Radboud Universitair Medisch Centrum; Endocrine Society of Australia; Monash University; Murdoch Children's Research Institute; Austin Medical Research Foundation; Radboud Universiteit; National Institute of Allergy and Infectious Diseases; Medical Research Council; Children’s Hospital of Wisconsin Research Institute; Institute of Infection and Immunity; Burnet Institute; Paul G. Allen Family Foundation","keywords":"Cyproterone acetate; Testosterone (patch); Cyproterone; Proteome; Hormone therapy; Hormone; Blood proteins; Leptin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186338,0.0001643089,0.0002878096,0.0002911027,0.0001729104,0.000243708,0.00007265696,0.0001235711,0.001031659],"category_scores_gemma":[0.0003296486,0.00007346366,0.0001760381,0.0002325395,0.0001684185,0.00009417858,0.0001705303,0.0001968058,0.000117049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868686,"about_ca_system_score_gemma":0.0001126605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009387187,"about_ca_topic_score_gemma":0.001218703,"domain_scores_codex":[0.9998751,0.00002889157,0.000008658418,0.00003545248,0.0000311246,0.00002073921],"domain_scores_gemma":[0.9998472,0.00002051117,0.00007044631,0.00001352733,0.00001735834,0.00003087832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005656859,0.0001174255,0.2992532,0.000180238,0.0003023697,0.001194639,0.0007069318,0.0003051498,0.6488056,0.000106582,0.0006924903,0.04267862],"study_design_scores_gemma":[0.00001435572,0.0006343463,0.9757825,0.00001090427,0.00006250732,0.0009970559,0.0002373666,0.0001696591,0.02010362,0.00005627041,0.00192338,0.000007974344],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974791,0.001340022,0.0002266387,0.00005620647,0.00001371359,0.000005102377,0.00046182,0.000009852775,0.0004075421],"genre_scores_gemma":[0.9982034,0.0004873054,0.0001926862,0.00009057196,0.00001075741,0.000008153373,0.0005134771,0.00000513291,0.0004886084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031659,"threshold_uncertainty_score":0.003451288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05363324169805701,"score_gpt":0.366059919104619,"score_spread":0.312426677406562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}