{"id":"W4415361592","doi":"10.1038/s41588-025-02333-9","title":"Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas","year":2025,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; Terry Fox Research Institute; U.S. Department of Health and Human Services; Howard Hughes Medical Institute","keywords":"Chromatin; ARID1A; SMARCA4; Chromatin remodeling; Function (biology); Cell growth; Gene; Cancer; Regulation of gene expression; Endometrial cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253259,0.000189535,0.0002158066,0.0005159483,0.0001622729,0.0005221103,0.0002892728,0.0002359067,0.001892878],"category_scores_gemma":[0.0003499852,0.0002808025,0.0002137752,0.0002393436,0.000266097,0.0002439842,0.0004123689,0.000364283,0.0004189251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003484562,"about_ca_system_score_gemma":0.0001307636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008891578,"about_ca_topic_score_gemma":0.001014336,"domain_scores_codex":[0.9998398,0.0000150652,0.0000240714,0.00003495584,0.00004686511,0.00003925635],"domain_scores_gemma":[0.9997687,0.00004475208,0.00004842686,0.00005608765,0.00003118698,0.00005088089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002008026,0.00001286615,0.004925238,0.00001679591,0.00001208651,0.0001732018,0.00004908155,0.0001197632,0.9928582,0.0002431884,0.00004012274,0.001348623],"study_design_scores_gemma":[0.00001849544,0.00009794984,0.1929915,0.000005731567,0.00003721489,0.00152266,0.0002978466,0.002348636,0.7997638,0.0003350421,0.002569308,0.00001185759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998464,0.0002541592,0.0006852052,0.00002106976,0.000003965065,0.000003976236,0.0001707415,0.00002971426,0.000367257],"genre_scores_gemma":[0.9987618,0.0000859008,0.0002296879,0.00001302393,0.00000175523,0.000004324563,0.0002151948,0.00001458673,0.0006736079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892878,"threshold_uncertainty_score":0.006332278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172313616882369,"score_gpt":0.258962458164506,"score_spread":0.2472393219956823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}