{"id":"W4415373268","doi":"10.3389/fimmu.2025.1688281","title":"The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Microbial Inactivation Methods","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Lung cancer; Electroporation; Immunotherapy; Flow cytometry; Irreversible electroporation; T cell; Regimen; Cancer immunotherapy; Tumor microenvironment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146896,0.0001170918,0.0001888828,0.00008005487,0.0001521078,0.00001504598,0.000138099,0.0001225977,0.000004519469],"category_scores_gemma":[0.0001080836,0.00008319374,0.00003917322,0.000206899,0.0002354721,0.000005982486,0.00004119266,0.00007139273,6.813784e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009117636,"about_ca_system_score_gemma":0.0001464096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003443097,"about_ca_topic_score_gemma":0.00005030397,"domain_scores_codex":[0.9986299,0.0006589738,0.0003060897,0.0001979324,0.0000501053,0.0001569978],"domain_scores_gemma":[0.9992888,0.0001107681,0.0002529911,0.0002491774,0.00008948596,0.000008770067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00110683,0.00009369361,0.003060545,0.0000192933,0.0002083206,1.992072e-7,0.0004050702,0.00003392575,0.9866866,0.00004840594,0.001177973,0.007159159],"study_design_scores_gemma":[0.001205598,0.0004126885,0.007215089,0.00001508408,0.00006390222,7.793102e-7,0.0005093059,0.0003543142,0.9878128,0.0001259652,0.002216303,0.0000681574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608637,0.03112351,0.006310488,0.0007775296,0.0002594129,0.0005844026,0.000008536336,0.000005813646,0.00006662121],"genre_scores_gemma":[0.9942254,0.003232745,0.0007351193,0.0000258068,0.00001212479,0.00004936336,0.00005933501,0.00001010684,0.001649938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03336178,"threshold_uncertainty_score":0.3392542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006041609162785909,"score_gpt":0.2798639301221391,"score_spread":0.2738223209593532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}