{"id":"W4415373914","doi":"10.1016/j.hlife.2025.10.002","title":"Dual strategies for durable antibodies against SARS-CoV-2: Immune trajectories and viral fitness constraints","year":2025,"lang":"en","type":"article","venue":"hLife","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Key Research and Development Program of China; Chinese Academy of Sciences; Canadian Anesthesiologists' Society","keywords":"Immune system; Dual (grammatical number); Antibody; Immune escape; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004222089,0.0005143937,0.0005375107,0.000291554,0.0002674127,0.001099795,0.0006108336,0.0007936981,0.005568707],"category_scores_gemma":[0.0004856208,0.0002156377,0.0003595877,0.0001674026,0.0003622044,0.0008599287,0.0007992149,0.001785869,0.0009559956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034058,"about_ca_system_score_gemma":0.0003591106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004252732,"about_ca_topic_score_gemma":0.001250393,"domain_scores_codex":[0.9996949,0.0000400365,0.00001238194,0.000060857,0.00005498203,0.0001368098],"domain_scores_gemma":[0.9998111,0.00004603112,0.00004281621,0.000020815,0.00002583713,0.00005338441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009518033,0.0006775651,0.001106899,0.0002072429,0.00008194399,0.0001421365,0.0001020376,0.005881176,0.9221317,0.007914531,0.001673957,0.05912899],"study_design_scores_gemma":[0.0007276544,0.01335478,0.005398989,0.0001173443,0.0003467275,0.00159698,0.0004895571,0.0464775,0.8639451,0.008111176,0.05934547,0.00008865321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586861,0.006063614,0.02234649,0.001300848,0.0002344514,0.0001606137,0.0003312465,0.000212753,0.01066386],"genre_scores_gemma":[0.9870683,0.0007740644,0.005686345,0.0003318788,0.00002981274,0.0000807677,0.0001587559,0.00002633034,0.005843742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005568707,"threshold_uncertainty_score":0.01862919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04128319147895346,"score_gpt":0.3590878123443154,"score_spread":0.3178046208653619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}