{"id":"W4415379673","doi":"10.1098/rsob.250171","title":"The evolutionary entanglement of flipons with zinc fingers and retroelements has engendered a large family of Z-DNA and G-quadruplex binding proteins","year":2025,"lang":"en","type":"article","venue":"Open Biology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Zinc finger; DNA-binding protein; DNA; Transcription factor; Nucleic acid; RNA-binding protein; RNA; Gene; Proteome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004438031,0.000398548,0.0003983526,0.0004455213,0.0005889825,0.0006715581,0.000575081,0.0006973482,0.001882662],"category_scores_gemma":[0.0006218288,0.0004327874,0.0006170992,0.0004429756,0.001377076,0.001603712,0.0009683141,0.001214888,0.0006382874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007596301,"about_ca_system_score_gemma":0.0003898983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008802275,"about_ca_topic_score_gemma":0.001082694,"domain_scores_codex":[0.9997756,0.00002842593,0.000009155622,0.00009593496,0.00005988824,0.00003104334],"domain_scores_gemma":[0.999627,0.0001293215,0.00008457412,0.0000796586,0.00003897779,0.00004042333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004040933,0.0002921526,0.01270682,0.000424094,0.0001419797,0.0006215895,0.000403987,0.01414083,0.7730917,0.0715257,0.0006811877,0.1255659],"study_design_scores_gemma":[0.0001181189,0.002074173,0.03337925,0.0001650819,0.0001987485,0.00350148,0.0005335236,0.03939779,0.7372867,0.07195524,0.1111568,0.0002331639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8696093,0.007714279,0.1074644,0.0006280586,0.000113346,0.0001078435,0.000380865,0.0005301075,0.01345186],"genre_scores_gemma":[0.9253762,0.00358947,0.06471644,0.0002909678,0.00003558149,0.00009145497,0.0005019797,0.00008419965,0.005313688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882662,"threshold_uncertainty_score":0.006298184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416356330038512,"score_gpt":0.2694629738009113,"score_spread":0.2552994105005262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}