{"id":"W4415387709","doi":"10.1038/s41598-026-53398-3","title":"LYL1 is critical for adult hematopoietic stem cell-derived B and T lymphopoiesis","year":2025,"lang":"en","type":"preprint","venue":"Scientific Reports","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Medical Research Council; University of Manitoba; National Health and Medical Research Council; CancerCare Manitoba Foundation","keywords":"Lymphopoiesis; Haematopoiesis; Progenitor cell; Conditional gene knockout; Transcription factor; Stem cell; Progenitor; Lineage (genetic); Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824428,0.0003716642,0.0002566409,0.0003532815,0.0003085304,0.0005809878,0.0002929782,0.0004913346,0.002245134],"category_scores_gemma":[0.000266227,0.0002410436,0.0002121482,0.000165931,0.0004112567,0.0002587129,0.0005176417,0.0006183933,0.001706668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970593,"about_ca_system_score_gemma":0.000473548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005127274,"about_ca_topic_score_gemma":0.0006235886,"domain_scores_codex":[0.9997901,0.00002527575,0.00002148774,0.00005360628,0.00006865292,0.00004085644],"domain_scores_gemma":[0.9996611,0.00002370995,0.0001265981,0.00001865255,0.00002622251,0.0001437506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751494,0.00001321557,0.0005391836,0.00004827107,0.000003430269,0.0001258258,0.00001727942,0.00007026293,0.9955152,0.0003672896,0.0001709166,0.002954035],"study_design_scores_gemma":[0.00005878653,0.0001961473,0.01563569,0.00002422409,0.00002321728,0.0009805575,0.00006765896,0.001585874,0.963653,0.000366765,0.01739522,0.00001286297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578184,0.01066177,0.02167748,0.0007100804,0.0001565918,0.00005669189,0.002485363,0.0009373314,0.005496284],"genre_scores_gemma":[0.9835012,0.001806641,0.005848131,0.000117707,0.00003480533,0.00005209043,0.002209556,0.0001651679,0.006264724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245134,"threshold_uncertainty_score":0.007510722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443753406008424,"score_gpt":0.3226020121780865,"score_spread":0.2981644781180022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}