{"id":"W4415388228","doi":"10.1101/2025.10.20.683168","title":"Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"IRF7; Downregulation and upregulation; Peripheral blood mononuclear cell; Immune system; Monocyte; Interferon; Lupus erythematosus; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833107,0.000307832,0.0003818664,0.0004183629,0.0001863334,0.0004145306,0.00009878825,0.000213117,0.002328901],"category_scores_gemma":[0.0002363559,0.0001470826,0.0004378507,0.0003599178,0.0002148502,0.0001548094,0.0002349617,0.0003073385,0.0005433718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593505,"about_ca_system_score_gemma":0.000157792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003555391,"about_ca_topic_score_gemma":0.0004854357,"domain_scores_codex":[0.999643,0.00006541366,0.00003315743,0.00011206,0.00008171851,0.00006466526],"domain_scores_gemma":[0.9998026,0.0000353833,0.00008143101,0.00002133509,0.00002738526,0.00003183761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007297556,0.0000248254,0.01919983,0.0002936973,0.00006929771,0.0001318145,0.0000615212,0.0002299324,0.9727802,0.00005965161,0.0002759633,0.006143368],"study_design_scores_gemma":[0.00008262622,0.0008293826,0.4766293,0.0001609433,0.0003360504,0.001774426,0.000348277,0.002630568,0.5072331,0.0007648212,0.009166795,0.00004372059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855924,0.00564381,0.002760444,0.0001341386,0.00004812536,0.00003068612,0.004779397,0.0001310648,0.0008799337],"genre_scores_gemma":[0.9934429,0.001220202,0.002189619,0.00014303,0.00002473608,0.00003580485,0.002285757,0.00002099702,0.0006368944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002328901,"threshold_uncertainty_score":0.007790983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796166702738303,"score_gpt":0.2924957736263811,"score_spread":0.2645341065989981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}