{"id":"W4415388552","doi":"10.1101/2025.10.20.683421","title":"HyperdCas12a-Based Multiplexed Genetic Regulation in <i>Candida albicans</i>","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Genetic screen; Gene; Functional genomics; Mutant; Ergosterol; Genomics; Phenotype; Efflux; Systems biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003301877,0.0004212377,0.0003489524,0.0003186806,0.0002446502,0.0007586046,0.0005597974,0.0003636062,0.001493954],"category_scores_gemma":[0.0002115529,0.0002141543,0.0002936314,0.0002452189,0.000399679,0.0001732,0.0004744493,0.0008276922,0.0005434442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006411627,"about_ca_system_score_gemma":0.0004449199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001753179,"about_ca_topic_score_gemma":0.001931671,"domain_scores_codex":[0.999584,0.00004095197,0.00004203056,0.0001223423,0.0001596144,0.00005095383],"domain_scores_gemma":[0.999786,0.00003053318,0.0000650189,0.00004229118,0.00002852551,0.00004767489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005199039,0.00002005544,0.0001000903,0.00002191457,0.000004458156,0.00003006704,0.000006987712,0.00025033,0.9974244,0.0002097044,0.0001492514,0.001730826],"study_design_scores_gemma":[0.000009225852,0.00005263061,0.0004934387,0.000002773119,0.00000460143,0.00007010334,0.000006708853,0.00181235,0.9953087,0.0000621234,0.002168064,0.000009224481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9259145,0.001561734,0.05824742,0.0006241199,0.0003132749,0.0002768411,0.002818091,0.002778318,0.007465646],"genre_scores_gemma":[0.961253,0.0005237215,0.03157575,0.0001884073,0.00002308204,0.000134709,0.0008302397,0.000294483,0.005176654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001753179,"threshold_uncertainty_score":0.00499779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271969683787023,"score_gpt":0.2367528108841423,"score_spread":0.2240331140462721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}