{"id":"W4415396204","doi":"10.1101/2025.10.17.25338235","title":"Novel blood protein biomarkers for distinguishing bacterial from non-bacterial infection in children: a case–control study","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Bacterial Identification and Susceptibility Testing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Public Health Agency; Hospital for Sick Children; Queen's University Belfast","keywords":"Biomarker; C-reactive protein; Diagnostic biomarker; Prospective cohort study; Antibiotics; Inflammation; Biomarker discovery; Diagnostic accuracy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002420746,0.0008514216,0.0008793694,0.001509622,0.0006999917,0.001011722,0.0006057151,0.001054491,0.001449138],"category_scores_gemma":[0.004876019,0.0007215209,0.0009233945,0.001178487,0.0009770148,0.0006516619,0.000600926,0.0007478918,0.0002238597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007335705,"about_ca_system_score_gemma":0.0005182331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003999608,"about_ca_topic_score_gemma":0.002590727,"domain_scores_codex":[0.9975097,0.0007810633,0.0002988865,0.0007666464,0.0004133241,0.0002302165],"domain_scores_gemma":[0.9959823,0.001470131,0.001357635,0.0003778741,0.0004485244,0.0003635217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005152676,0.0001020268,0.997328,0.00004053697,0.0001386613,0.000267022,0.0001238214,0.0000390706,0.0004679292,0.00002457902,0.00005933106,0.0008937295],"study_design_scores_gemma":[0.0001028736,0.001346633,0.99471,0.0000298052,0.0002032031,0.002058144,0.0002846655,0.0004507526,0.0003327226,0.00002670579,0.0004400797,0.00001450795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986793,0.0006138916,0.0003468298,0.00001735365,0.000009771439,0.00005511192,0.0001366515,0.000003624405,0.0001374197],"genre_scores_gemma":[0.9990871,0.0001657367,0.0004020389,0.0000239784,0.00001767713,0.00005247054,0.0001861641,0.000003355052,0.00006144932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003999608,"threshold_uncertainty_score":0.01280224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142984260970629,"score_gpt":0.2677493265013139,"score_spread":0.253450900404251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}