{"id":"W4415396832","doi":"10.1101/2025.10.19.25338308","title":"Oxidative Stress, Neuroinflammation, and Neuronal Vulnerability Begin in Midlife: a 7 Tesla Magnetic Resonance Spectroscopy Healthy Adult Lifespan Study","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Sunnybrook Health Science Centre; Institut Universitaire de Gériatrie de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau en Bio-Imagerie du Quebec","keywords":"Oxidative stress; White matter; Aging brain; Brain aging; Magnetic resonance imaging; Healthy aging; Ageing; Glutathione; Posterior cingulate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003933863,0.0003046891,0.0002937955,0.0004439466,0.0003657642,0.0004614044,0.0001975949,0.0003740452,0.00250454],"category_scores_gemma":[0.0004301177,0.0001209727,0.0002745295,0.0003453011,0.0001423543,0.0002472854,0.0003466493,0.0002571944,0.0003954091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001464052,"about_ca_system_score_gemma":0.0001443075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154389,"about_ca_topic_score_gemma":0.003393995,"domain_scores_codex":[0.9999384,0.00001110147,0.000005358256,0.0000261783,0.000006334647,0.00001263702],"domain_scores_gemma":[0.9997244,0.0000253193,0.00009778014,0.00002809239,0.00005453923,0.00006986706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006225016,0.0003935899,0.8690533,0.0008952108,0.001694815,0.001461171,0.001276207,0.0003310585,0.04794086,0.0005937255,0.01148164,0.05865343],"study_design_scores_gemma":[0.00003595166,0.0003724851,0.9930039,0.00004945051,0.0002637872,0.0006173894,0.000282209,0.0001098321,0.001838094,0.0005137135,0.002899781,0.00001333369],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914703,0.002701807,0.0006132561,0.0004250301,0.00003572306,0.00002525551,0.003578205,0.00003127047,0.001119167],"genre_scores_gemma":[0.9936953,0.001296826,0.001070157,0.0002178534,0.00008098663,0.00003260919,0.002460886,0.000009994255,0.001135409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250454,"threshold_uncertainty_score":0.008378506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443280110498982,"score_gpt":0.2995845811056702,"score_spread":0.2751517800006804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}