{"id":"W4415397430","doi":"10.1021/acsbiomedchemau.5c00174","title":"Manipulation of 7-Finger Zinc Finger Nuclease Increases the Efficiency of Genome Editing in Human Cells","year":2025,"lang":"en","type":"article","venue":"ACS Bio & Med Chem Au","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Co-creation place formation support program; Foundation of Kinoshita Memorial Enterprise","keywords":"Zinc finger nuclease; Genome editing; Transcription activator-like effector nuclease; Zinc finger; Genome; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003852436,0.000330821,0.0003315475,0.0002307579,0.0001352682,0.0004179251,0.0002746953,0.0003981552,0.001437755],"category_scores_gemma":[0.0003099958,0.0001127732,0.0003511695,0.0001779337,0.0002200843,0.000209006,0.0003643705,0.0004974716,0.000537705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259364,"about_ca_system_score_gemma":0.000250509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003489311,"about_ca_topic_score_gemma":0.0005511317,"domain_scores_codex":[0.9996568,0.00005800363,0.00003787775,0.00009971714,0.0001133531,0.00003426025],"domain_scores_gemma":[0.9998748,0.00003335702,0.00003133743,0.00002959657,0.00001514385,0.00001567912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002636942,0.00001319586,0.0001146635,0.00003138223,0.000007066153,0.00005761847,0.00001140024,0.0001198473,0.9944706,0.0003357553,0.00007920765,0.004732877],"study_design_scores_gemma":[0.000005955203,0.00006906901,0.0005911051,0.000004522023,0.00001441899,0.0002395379,0.000006796075,0.001039095,0.9919653,0.0000992247,0.005959288,0.000005753284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8122717,0.004743026,0.1672845,0.0004195469,0.0001869983,0.0001916809,0.000837104,0.00158345,0.01248188],"genre_scores_gemma":[0.9487441,0.00172319,0.04460604,0.0001190323,0.00002361489,0.00005174381,0.0006549311,0.0001116632,0.003965753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437755,"threshold_uncertainty_score":0.004809737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00703942672227873,"score_gpt":0.2720233506160614,"score_spread":0.2649839238937826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}