{"id":"W4415401149","doi":"10.3390/toxins17100520","title":"How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada","keywords":"Sodium; Protonation; Permeation; Batrachotoxin; Ion; Calcium; Sodium channel; Deprotonation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008464565,0.000158806,0.0001274449,0.00005303651,0.0002057251,0.00008335608,0.0000936757,0.0002084202,0.00002095141],"category_scores_gemma":[0.00004903115,0.000152037,0.0000744773,0.0001221665,0.0001262553,0.00001118238,0.00008434814,0.00009646872,0.000008881993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001794501,"about_ca_system_score_gemma":0.00006041613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002087959,"about_ca_topic_score_gemma":0.00004384026,"domain_scores_codex":[0.9991579,0.00003681275,0.0001317301,0.0003420706,0.0000951188,0.0002363389],"domain_scores_gemma":[0.999543,0.00001074862,0.00004699445,0.0002572034,0.00007745594,0.00006456507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002874659,0.0002727786,0.0007304826,0.0001193513,0.0002154684,0.000008343688,0.0005372082,0.00007607642,0.8761014,0.009871828,0.1082475,0.00353209],"study_design_scores_gemma":[0.001346037,0.0002017309,0.003747312,0.00002465867,0.00004948581,0.00002293122,0.000790996,0.001067412,0.4040134,0.001726219,0.586624,0.0003858036],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8332528,0.001886834,0.1055721,0.02452832,0.00433702,0.0007600921,0.00009092809,0.0001392286,0.02943265],"genre_scores_gemma":[0.9648243,0.0001440643,0.0001700667,0.001160781,0.0005838927,0.00003292599,0.0001299575,0.00001565352,0.03293837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4783764,"threshold_uncertainty_score":0.6199889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015067810117353,"score_gpt":0.2661107033756269,"score_spread":0.2459600252744533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}