{"id":"W4415401149","doi":"10.3390/toxins17100520","title":"How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada","keywords":"Sodium; Protonation; Permeation; Batrachotoxin; Ion; Calcium; Sodium channel; Deprotonation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006211544,0.0001739018,0.0002391801,0.00008833114,0.0005506625,0.0004120996,0.0004350363,0.0004063153,0.001164414],"category_scores_gemma":[0.0001863219,0.0001946718,0.0003520472,0.0001013883,0.0003710694,0.0006673498,0.0001907067,0.0003151357,0.0001189462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007868501,"about_ca_system_score_gemma":0.0008652787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0105814,"about_ca_topic_score_gemma":0.01330664,"domain_scores_codex":[0.9999564,0.000004620501,0.000001580549,0.00000811132,0.00001386451,0.0000154983],"domain_scores_gemma":[0.999962,0.000006362945,0.000007067657,0.000003824365,0.00001027352,0.00001052389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004263397,0.0001160599,0.01565306,0.0002197868,0.0001828101,0.0006642013,0.000277622,0.7117097,0.2496826,0.01316508,0.0008564261,0.007046178],"study_design_scores_gemma":[0.00008849666,0.0002490101,0.00694218,0.00002144808,0.00006786046,0.0002069498,0.000212744,0.9548227,0.03294262,0.003342251,0.001065118,0.00003862367],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930058,0.000213349,0.00504463,0.0001754034,0.00001417415,0.00000868046,0.0000806286,0.00004396873,0.001413313],"genre_scores_gemma":[0.9971552,0.0002370368,0.001808491,0.00004167104,0.000002381293,0.00001057872,0.0001410519,0.00001777695,0.0005858194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105814,"threshold_uncertainty_score":0.02103961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015067810117353,"score_gpt":0.2661107033756269,"score_spread":0.2459600252744533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}