{"id":"W4415403106","doi":"10.51731/cjht.2025.1258","title":"Acalabrutinib (Calquence)","year":2025,"lang":"","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bendamustine; Mantle cell lymphoma; Debulking; Rituximab; Lymphoma; Primary central nervous system lymphoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004465439,0.0003136978,0.0003239923,0.0008400513,0.0005370239,0.0009835098,0.0006796029,0.0008793586,0.04543769],"category_scores_gemma":[0.001000715,0.0001042217,0.0003870543,0.000613054,0.0002943175,0.0003722651,0.0005295607,0.001432883,0.01300918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002907718,"about_ca_system_score_gemma":0.003193133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03554582,"about_ca_topic_score_gemma":0.08722455,"domain_scores_codex":[0.9996928,0.00003166162,0.0000122508,0.00004835765,0.0001461218,0.00006885966],"domain_scores_gemma":[0.9995497,0.0000320247,0.0000522101,0.00002435767,0.0001479658,0.0001937387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000788544,0.0002313362,0.001594203,0.0004059756,0.00004809895,0.0003619056,0.00003017255,0.0002057514,0.004833706,0.00381606,0.3901427,0.5975415],"study_design_scores_gemma":[0.00084445,0.0002771439,0.003603816,0.0001217874,0.00002850996,0.0008852211,0.00001119915,0.0001463057,0.001310643,0.0004931092,0.9922696,0.00000805303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.03568729,0.1340588,0.002546021,0.03192094,0.002708808,0.0009186854,0.01525125,0.002527888,0.7743803],"genre_scores_gemma":[0.3774982,0.08259615,0.01072255,0.03659347,0.00223475,0.0007172514,0.04360513,0.0003701489,0.4456624],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.04543769,"threshold_uncertainty_score":0.1520042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0282575480796171,"score_gpt":0.3551830520183717,"score_spread":0.3269255039387546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}