{"id":"W4415407816","doi":"10.1161/circulationaha.125.075402","title":"Direct Therapeutic Modulation of RYR2 Activity by CMYA5","year":2025,"lang":"en","type":"letter","venue":"Circulation","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute","keywords":"Modulation (music); Ryanodine receptor 2; Calcium; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005914228,0.0003872802,0.0006465504,0.0001807392,0.0004207198,0.0008368176,0.000386826,0.003420764,0.003034224],"category_scores_gemma":[0.001523646,0.0001408769,0.000457191,0.0001280742,0.0009287117,0.0004110711,0.0002771034,0.00547922,0.001386066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001003994,"about_ca_system_score_gemma":0.0003057708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889718,"about_ca_topic_score_gemma":0.0006200298,"domain_scores_codex":[0.9997573,0.00006675092,0.00002171823,0.0000367532,0.00006973535,0.00004777712],"domain_scores_gemma":[0.9995885,0.0002559791,0.00004023463,0.00003247795,0.00002310267,0.00005956793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009770122,0.001000526,0.003857198,0.000965632,0.0002304921,0.0296651,0.0002493037,0.0009468411,0.08197206,0.03938521,0.6022081,0.2297494],"study_design_scores_gemma":[0.004970791,0.002648721,0.007443452,0.0003423104,0.0002000323,0.0187543,0.0001923578,0.004456339,0.06691179,0.03059536,0.8633828,0.0001018339],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.06678846,0.04012532,0.005335539,0.7868382,0.053309,0.000186133,0.0004249015,0.0004739987,0.04651841],"genre_scores_gemma":[0.5696145,0.02221842,0.004919205,0.2696241,0.08870955,0.0005401306,0.0002472353,0.0001237576,0.04400318],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003420764,"threshold_uncertainty_score":0.01015055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387535913396954,"score_gpt":0.241396690260211,"score_spread":0.2275213311262415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}