{"id":"W4415407816","doi":"10.1161/circulationaha.125.075402","title":"Direct Therapeutic Modulation of RYR2 Activity by CMYA5","year":2025,"lang":"en","type":"letter","venue":"Circulation","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute","keywords":"Modulation (music); Ryanodine receptor 2; Calcium; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001077167,0.0002390986,0.0002483627,0.0000940695,0.00005376683,0.00002075098,0.0001345611,0.0008768311,0.00002771707],"category_scores_gemma":[0.00002694916,0.0002667995,0.0001822442,0.000138549,0.00005820506,0.00001033083,0.00001929709,0.0002403631,0.000004711002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006027674,"about_ca_system_score_gemma":0.00007295456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003566031,"about_ca_topic_score_gemma":0.000004257173,"domain_scores_codex":[0.9986767,0.0001564978,0.0002737058,0.0004489761,0.0002706145,0.0001734795],"domain_scores_gemma":[0.9990776,0.00002075129,0.0002614273,0.0004725585,0.0001483679,0.00001927569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002837272,0.00002724422,0.001939991,0.0001469438,0.0001098004,3.768452e-7,0.00001453416,0.0006942991,0.8407202,0.000007487538,0.1517417,0.004569102],"study_design_scores_gemma":[0.0007088571,0.00007058332,0.1172457,0.00009944264,0.0001965957,0.000002801574,0.000003500619,0.002771285,0.24022,0.00022481,0.6378247,0.0006317034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7568628,0.003300584,0.1151064,0.1099165,0.002794746,0.002852779,0.001036038,0.0002254669,0.007904566],"genre_scores_gemma":[0.9805022,0.00004123587,0.00003658061,0.01249908,0.0004678628,0.00002457656,0.005438743,0.00003512864,0.0009545415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6005002,"threshold_uncertainty_score":0.9999784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387535913396954,"score_gpt":0.241396690260211,"score_spread":0.2275213311262415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}