{"id":"W4415423439","doi":"10.1093/ndt/gfaf116.1236","title":"#2936 Origin 3 study design: a global, randomized, controlled, Phase 3 study of atacicept in IgA nephropathy","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Nephropathy; Proteinuria; Kidney disease; Population; Glomerulonephritis; Clinical endpoint; Immune system; Diabetic nephropathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00410287,0.002375493,0.004787822,0.0006200957,0.0006706803,0.001701131,0.001317015,0.002189699,0.01944179],"category_scores_gemma":[0.001543122,0.0007887463,0.002423355,0.0007171052,0.001350255,0.00146551,0.0006073907,0.003723474,0.002621132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008892192,"about_ca_system_score_gemma":0.002416269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007658635,"about_ca_topic_score_gemma":0.002234482,"domain_scores_codex":[0.9984067,0.0008527579,0.00008280665,0.0003010803,0.0001299511,0.0002266494],"domain_scores_gemma":[0.9990205,0.0001856441,0.0002018529,0.000081856,0.0001092968,0.0004008962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9667816,0.01054703,0.000426743,0.001186462,0.001280824,0.00005060331,0.00003365417,0.0002802228,0.003809972,0.0002626245,0.002022376,0.01331772],"study_design_scores_gemma":[0.9510117,0.04611203,0.0007486301,0.00003545759,0.0003380736,0.00002034599,0.000009019521,0.000216716,0.0002040241,0.0001457558,0.001145154,0.00001308042],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8844606,0.0194074,0.006718355,0.002921504,0.003951721,0.06146694,0.008122328,0.001081843,0.0118693],"genre_scores_gemma":[0.8951519,0.006726683,0.01229212,0.008441836,0.002184116,0.05780535,0.00327134,0.0001892212,0.01393739],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01944179,"threshold_uncertainty_score":0.06503922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548861762231602,"score_gpt":0.3248375355452418,"score_spread":0.3093489179229258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}