{"id":"W4415425564","doi":"10.1093/ndt/gfaf116.0406","title":"#1491 Low rate of infusion-related reactions and high treatment adherence with obinutuzumab in patients with active lupus nephritis: analysis of the NOBILITY and REGENCY studies","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Obinutuzumab; Placebo; Adverse effect; Clinical endpoint; Rash; Lupus nephritis; Belimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01687668,0.0004255376,0.001327595,0.001365563,0.0005029011,0.001533562,0.0009905867,0.001117277,0.003391082],"category_scores_gemma":[0.03070076,0.0003159766,0.002945307,0.002144289,0.0005392891,0.001064706,0.001220138,0.001125587,0.0002729883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843991,"about_ca_system_score_gemma":0.0003419474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007252141,"about_ca_topic_score_gemma":0.0010586,"domain_scores_codex":[0.9765099,0.01445348,0.003926463,0.001890901,0.002695716,0.0005235773],"domain_scores_gemma":[0.9444024,0.02408204,0.02399482,0.003823183,0.002364082,0.001333433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007790173,0.0001327049,0.9721443,0.000826183,0.007849176,0.0001479984,0.0001616645,0.00008629508,0.0002823318,0.0001643914,0.0007489318,0.009665716],"study_design_scores_gemma":[0.0008286953,0.001618935,0.9902567,0.0002232648,0.003274666,0.0005828353,0.0001790795,0.0003745249,0.0001186499,0.0001441319,0.002368497,0.00003000916],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973012,0.02096425,0.0006046646,0.0004624672,0.00008618894,0.0003484797,0.002384955,0.000009823576,0.002127155],"genre_scores_gemma":[0.9972583,0.0008173941,0.0002600515,0.0002411507,0.00008683577,0.0001568327,0.0009792007,0.000007756184,0.0001924231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01687668,"threshold_uncertainty_score":0.08925349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009977287892652327,"score_gpt":0.2708668784401987,"score_spread":0.2608895905475464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}