{"id":"W4415426380","doi":"10.1093/ndt/gfaf116.019","title":"#3413 Targeted treatment with pegcetacoplan for adolescents with C3G or primary (idiopathic) IC-MPGN in the VALIANT Phase 3 trial","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Testicular diseases and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Proteinuria; Renal function; Population; Placebo; Kidney; Glomerulopathy; Kidney disease; Alternative complement pathway; Podocin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006796424,0.0005045701,0.0009525974,0.0001630065,0.0002234417,0.0007608235,0.0003624978,0.0008198192,0.00358378],"category_scores_gemma":[0.0006181166,0.0001694162,0.001409058,0.0002202625,0.0002670863,0.0004433372,0.0002258871,0.002123156,0.0005240269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005424925,"about_ca_system_score_gemma":0.0008419369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008344587,"about_ca_topic_score_gemma":0.002207704,"domain_scores_codex":[0.9997979,0.0001030728,0.00001063762,0.00002693692,0.00002176109,0.00003973872],"domain_scores_gemma":[0.9996928,0.00006975932,0.00006936228,0.0000155514,0.00003705288,0.0001154599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5865766,0.007523544,0.01327892,0.005125329,0.006101514,0.0004855117,0.0003046669,0.004385843,0.01540161,0.002473523,0.03378202,0.3245609],"study_design_scores_gemma":[0.7824865,0.1409868,0.0330052,0.001322177,0.002959978,0.0009512021,0.0001587538,0.003350201,0.002690442,0.0016749,0.03035498,0.00005889569],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374239,0.0414842,0.00106239,0.002845972,0.0006186348,0.001569234,0.004125845,0.0002844853,0.01058536],"genre_scores_gemma":[0.9725565,0.01188788,0.001944905,0.00395449,0.0002649788,0.001506929,0.003995204,0.00004038627,0.003848663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00358378,"threshold_uncertainty_score":0.011989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670571585797316,"score_gpt":0.2938012439156215,"score_spread":0.2770955280576484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}