{"id":"W4415426982","doi":"10.1093/ndt/gfaf116.0244","title":"#3089 Suppression of complement alternative pathway by monthly dosing of sefaxersen, a novel antisense oligonucleotide therapy in development for IgAN","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Alternative complement pathway; Proteinuria; Complement system; Factor H; Classical complement pathway; Dosing; Nephropathy; Pathogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002100322,0.0002904155,0.0002346279,0.0001673557,0.0001506271,0.0002021888,0.0001998703,0.0004288363,0.006430758],"category_scores_gemma":[0.00009725061,0.00006520414,0.0001791619,0.00007877821,0.0001283223,0.0001693035,0.00009363172,0.0004354842,0.0008246125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508407,"about_ca_system_score_gemma":0.0004031951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005117711,"about_ca_topic_score_gemma":0.001158682,"domain_scores_codex":[0.9999245,0.0000177932,0.000008198507,0.00001373608,0.00002163666,0.00001400644],"domain_scores_gemma":[0.9999579,0.000006208585,0.00001015668,0.000002272619,0.000008461433,0.00001505247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009049875,0.001282741,0.0009218159,0.0003964866,0.00004393441,0.0003565939,0.00006457084,0.0002319425,0.7914299,0.0008765698,0.00469024,0.1906554],"study_design_scores_gemma":[0.0102553,0.1043539,0.02548635,0.0002641902,0.0002808607,0.00277898,0.0001568775,0.004249072,0.558695,0.0006678455,0.292753,0.00005862525],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437057,0.02097149,0.007486672,0.001823423,0.000862989,0.001196273,0.001488848,0.0005009779,0.02196367],"genre_scores_gemma":[0.9413647,0.00840803,0.01097095,0.0008292952,0.0001470579,0.0009039138,0.00115016,0.0000420412,0.03618393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006430758,"threshold_uncertainty_score":0.02151299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255493760299423,"score_gpt":0.2515864502731934,"score_spread":0.2390315126701991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}