{"id":"W4415434667","doi":"10.1093/ndt/gfaf116.1358","title":"#558 Population pharmacokinetic modelling of canagliflozin in advanced chronic kidney disease","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University; Université de Montréal; McGill University Health Centre","funders":"","keywords":"Canagliflozin; Kidney disease; Covariate; Pharmacokinetics; Population; Cohort; Dialysis; Renal function","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001534851,0.0005585327,0.0008790251,0.0003833132,0.0002508804,0.0008433794,0.0007250718,0.0008800845,0.001537264],"category_scores_gemma":[0.003425042,0.0003361789,0.0009213471,0.0003853049,0.0003484617,0.0003978932,0.0004878592,0.0008447873,0.0002514163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006674779,"about_ca_system_score_gemma":0.001074323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01555612,"about_ca_topic_score_gemma":0.006672138,"domain_scores_codex":[0.9994742,0.0002691558,0.00001698152,0.0001164486,0.00007451753,0.000048671],"domain_scores_gemma":[0.9986752,0.001002553,0.0001304442,0.00004097279,0.0001167057,0.00003408475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001393486,0.00008023673,0.00822548,0.00004740897,0.0001437358,0.0001028026,0.00004334465,0.9811583,0.0006707199,0.001648598,0.0004660294,0.007274016],"study_design_scores_gemma":[0.00001605939,0.00004484017,0.001472296,0.000003706787,0.00001870448,0.00001837753,0.000005781425,0.9972831,0.00008429305,0.0007600768,0.0002870906,0.000005651679],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5664904,0.0008069534,0.4245477,0.0006387421,0.00005707167,0.0003199509,0.002601489,0.0004237246,0.004113893],"genre_scores_gemma":[0.9722525,0.0002844047,0.02338172,0.00008757028,0.00002824937,0.0004375642,0.0009604503,0.0000323834,0.002535133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01555612,"threshold_uncertainty_score":0.03093117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100020375184463,"score_gpt":0.2639914702021437,"score_spread":0.2539894326836974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}