{"id":"W4415434951","doi":"10.1093/ndt/gfaf116.1970","title":"#644 A phase 2b dose finding study to assess the efficacy of RMC-035 on renal function in participants at high risk for kidney injury following open-chest cardiac surgery (POINTER)","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Royal Victoria Hospital; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Clinical endpoint; Renal function; Adverse effect; Acute kidney injury; Cardiac surgery; Kidney disease; Cardiopulmonary bypass; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003309576,0.00148493,0.002671561,0.0004399327,0.000600652,0.001150733,0.001195032,0.002836305,0.01517125],"category_scores_gemma":[0.00247524,0.0006761008,0.001737582,0.0004238223,0.001011028,0.001010638,0.0004888664,0.003576904,0.002172596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007150154,"about_ca_system_score_gemma":0.001797287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000802365,"about_ca_topic_score_gemma":0.001942663,"domain_scores_codex":[0.9990332,0.0005537845,0.00005980411,0.0001358174,0.00008792002,0.000129486],"domain_scores_gemma":[0.9982827,0.0004295488,0.0003873416,0.0001054244,0.0002036209,0.0005913579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9367037,0.02386944,0.001571076,0.001036498,0.001389429,0.00007565817,0.00006536826,0.0002903639,0.007814999,0.0002207448,0.003262387,0.02370029],"study_design_scores_gemma":[0.8275294,0.1685064,0.002086665,0.00004230146,0.0003361102,0.00002750675,0.00001414899,0.000181504,0.0003426414,0.000114812,0.0008038554,0.00001463808],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618375,0.006885006,0.001438553,0.002595171,0.0007268098,0.01639486,0.004882584,0.0003980761,0.004841567],"genre_scores_gemma":[0.9592905,0.002943204,0.005402707,0.005485387,0.0006905613,0.01637222,0.003042684,0.00005259466,0.006720034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01517125,"threshold_uncertainty_score":0.05075294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06821229625668637,"score_gpt":0.3985040404388787,"score_spread":0.3302917441821923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}